Small humanin-like peptide 1 (SHLP1)

Also known as SHLP1

A 26-residue MT-RNR2-associated research peptide with an unresolved receptor target and limited functional characterisation.

Length: 26 amino acids
Half-life: Not well characterised
Mechanism: SHLP1 has no established receptor target or well-defined signalling mechanism. Its designation reflects a predicted short open reading frame within the mitochondrial MT-RNR2 region, rather than demonstrated engagement of humanin receptors.
Studied in: Synthetic SHLP1 is used in exploratory cell-based comparisons of mitochondrial-derived peptides, including assays of viability, apoptosis and cellular stress.

About Small humanin-like peptide 1 (SHLP1)

Small humanin-like peptide 1 belongs to a set of six candidate peptides described in 2016 following analysis of short open reading frames within the mitochondrial 16S ribosomal RNA region, MT-RNR2. The predicted SHLP1 product contains 26 amino acids. Its name groups it with humanin-related mitochondrial peptide research, but does not establish a shared receptor or identical biological activity. Synthetic SHLP1 provides a defined reagent for testing the properties of the proposed peptide sequence.

Compared with SHLP2 and SHLP3, SHLP1 has received relatively limited functional investigation. A specific receptor, direct molecular binding partner and reproducible downstream signalling cascade have not been established. Exploratory studies therefore need to distinguish sequence-dependent effects from general assay interference or preparation-related effects. Cellular viability, apoptosis markers and mitochondrial measurements can serve as screening endpoints, but none alone demonstrates a mechanism. Evidence obtained with a synthetic peptide also does not independently establish its endogenous production or abundance.

Laboratory notes

Verify the complete sequence and terminal chemistry against the intended literature reference; the SHLP numbering does not imply interchangeable structures.
Establish solubility and recovery in the actual assay buffer, using matched vehicle blanks and checks for precipitation or surface adsorption.
For research use only. Pair viability measurements with orthogonal assays and peptide-only blanks to identify readout interference.

Storage and reconstitution basics: storage guide.

Questions about Small humanin-like peptide 1 (SHLP1)

Does SHLP1 bind the same receptors as humanin?

Shared receptor binding has not been established. The family name is not evidence of activity at FPR2 or the proposed humanin cytokine-receptor complex.

Where does the SHLP1 sequence originate?

It was proposed from a short open reading frame within the mitochondrial MT-RNR2 region, which also encodes 16S ribosomal RNA.

Does activity of synthetic SHLP1 prove endogenous peptide expression?

No. Endogenous expression requires separate evidence, ideally including sequence-specific detection with appropriate analytical controls.

Is Small humanin-like peptide 1 (SHLP1) for human use?

No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.

Related research peptides

All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.