How many vials are in a MOTS-c kit?

Every kit is 10 vials. The "5mg" label means 5 mg per vial, so a 5 mg kit gives 50 mg total, a 10 mg kit gives 100 mg total, and so on.

Is the price per vial or per kit?

Prices shown are for the full 10-vial kit. We always show the per-vial and per-mg breakdown so you can compare honestly.

What payment methods do you accept?

SEPA bank transfer (IBAN) is our default — secure, fee-free, instant confirmation. We can also send a secure card-payment link on request via WhatsApp.

Do you ship outside the EU?

Yes — UK, USA, Middle East, Asia and Australia. EU is fastest (5–18 business days). International is tracked and discreet. Some destinations are restricted — checkout will tell you.

How is purity verified?

Every batch is independently tested by HPLC and mass spectrometry. We can send the batch-specific COA for your order on request.

Is this intended for human use?

No. MOTS-c sold by Regena Peptides is a research compound supplied strictly for in-vitro laboratory investigation by qualified professionals. Not for human or veterinary use.

What is a mitochondrial-derived peptide?

A short peptide encoded within mitochondrial DNA rather than the nuclear genome. MOTS-c, humanin and the SHLPs are the best-characterised examples.

What is the reported half-life?

Short in circulation, with downstream AMPK-mediated effects on cellular metabolism persisting beyond plasma exposure in preclinical models.

Storage recommendations?

Lyophilised at −20 °C; reconstituted solution refrigerated at 2–8 °C.

Is MOTS-c approved for human use?

No — supplied strictly as a research reference compound.

Is MOTS-c banned in sport?

MOTS-c is not currently listed by name on the WADA Prohibited List, but the S0 (non-approved) category may still apply. Always check the current-year list.

What purity is guaranteed?

HPLC ≥99% with mass-spectrometry confirmation, with batch-specific COAs on request.

Available documentation

Tracked worldwide shipping

Secure bank transfer

Research use only

Longevity · Research kit

MOTS-claboratory reference kit

Kit of 10 vials

Mitochondrial-derived peptide used in exercise-mimetic and AMPK research.

Class: Mitochondrial-derived peptide (16 aa)
Half-life: Short
Kit: 10 vials
Use: Research only

Kit of 10 vials · 40mg per vial

Best value

€419.00

€41.90 per vial · €1.05/mg

Sold as 10-vial kits · minimum order

We don't sell single vials. Every order is a sealed 10-vial research kit with the size and full kit price shown before ordering.

✓ Batch documentation — ask for documentation matching the batch available to order.
✓ Clear format — the selected vial size, vial count and total kit price stay visible before adding to cart.

Choose your kit size

1 kit = 10 vials. Compare the full kit prices below.

Quantity

Every MOTS-c option — one tap to send us the list10mg kit (10 vials) — €279.0040mg kit (10 vials) — €419.00Tap to open WhatsApp with every option already typed — we'll tell you which kit fits your research, and suggest anything else worth looking at.

✓ Sealed 10-vial kit (small glass bottles, lyophilised powder)
✓ Ask for the Certificate of Analysis available for this batch
✓ Tracked worldwide shipping from Germany, the USA or China · allow 5–18 business days from tracking
! You'll also need bacteriostatic water to mix your peptides

DocumentationAsk before ordering
Tracked delivery5–18 business days
Research use onlySee policy

Secure checkout · Wise card and bank-transfer options · Germany, USA or China fulfilment

Estimated delivery

Choose your country to see a delivery estimate.

Questions about MOTS-c? Message us about available sizes and documentation.

Payment options at checkout. Choose Wise or Monzo card payment, or pay by SEPA / international bank transfer.

Tracked worldwide shipping. Discreet packaging from Germany, the USA or China; allow 5–18 business days after tracking is issued. Shipping details.

Independent HPLC + MS test: 99.45%. View batch aura004 COA · how to read it.

Read our purity policy or contact us before ordering.

View full MOTS-c buyer page →

€ Price per mg — honest breakdown

Every MOTS-c kit ships as 10 vials. Here's the exact maths so you can see which strength gives you the most peptide per euro. Larger kits are usually significantly cheaper per mg.

Kit price

€419.00

40 mg × 10 vials

Per vial

€41.90

€419.00 ÷ 10 vials

Total mg in kit

400 mg

40 mg × 10

Per mg

€1.05

€419.00 ÷ 400 mg

Compare every kit

Kit	Kit price	Per vial	Per mg
10 mg / vial	€279.00	€27.90	€2.79
40 mg / vialBest €/mg	€419.00	€41.90	€1.05

What is MOTS-c?

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region. Research describes AMPK activation and modulation of the folate/methionine cycle in exercise-mimetic models.

Mechanism of action

Activates AMPK and modulates folate/methionine cycle.

Primary research areas

Metabolic flexibility, exercise mimetic studies.

Research notes

Encoded within mitochondrial DNA, distinguishing it from nuclear-encoded peptides.

MOTS-c research guide

What MOTS-c is and why researchers study it

MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) was identified in 2015 as one of the first peptides translated from a small open reading frame inside the mitochondrial genome. Published preclinical work has linked MOTS-c administration to improved insulin sensitivity, AMPK pathway activation, enhanced metabolic flexibility and resistance to age-related metabolic decline in rodent models.

Because the molecule sits at the interface of mitochondrial biology, longevity research and metabolic-disease modelling, MOTS-c has become a staple in laboratory panels focused on cellular energetics, mitokine signalling and exercise-mimetic pathways.

How Regena tests every MOTS-c batch

Each MOTS-c production lot is verified by an independent European peptide laboratory before any vial is released.

Janoshik Analytical is the default verification partner. Per-batch PDFs are published on the lab reports page and tied to the batch number printed on every vial cap.

Storage, reconstitution and laboratory handling

Lyophilised MOTS-c is dispatched as a sterile white powder under inert atmosphere. Hold the unopened vial at 2–8 °C; transfer to −20 °C if the kit will not be reconstituted within 8–12 months. Reconstitute with bacteriostatic water for a two-month (60-day) in-use stability window under refrigeration.

Most laboratories use 5–10 mg/ml stock concentrations and aliquot before any freeze. Avoid vortex aggression — swirl the vial until the cake fully dissolves. MOTS-c is generally well-behaved during reconstitution; cloudy or coloured solutions are a red flag for handling error or undisclosed impurities.

MOTS-c vs AOD-9604 vs SS-31

Researchers comparing mitochondrial and metabolic peptides often place MOTS-c alongside SS-31 (Elamipretide) for inner-membrane bioenergetic work and AOD-9604 for adipose-tissue lipolysis modelling. MOTS-c sits in a distinct mechanistic lane via AICAR-like AMPK activation; SS-31 modulates cardiolipin interaction at the inner mitochondrial membrane; AOD-9604 acts on β3-adrenergic fat-mobilisation pathways.

Stocking all three from the same supplier keeps batch documentation and packaging consistent across a comparative panel.

What to demand from any MOTS-c supplier

An honest MOTS-c supplier publishes a per-batch third-party COA, names the testing laboratory and prints the batch number on the vial. Reject suppliers showing a single static COA across all production runs or refusing to identify their analytical partner — those are reliable indicators of unverified material.

Regena's consultations team is happy to walk a new buyer through the COA, the reconstitution maths and the storage plan before any order is dispatched.

MOTS-c: expanded research context

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. It is one of a small family of mitochondrial peptides (with humanin and SHLPs) that appear to signal in an endocrine-like manner about mitochondrial metabolic state. Research interest centres on AMPK activation, glucose homeostasis and exercise-mimetic pathways.

In preclinical work, MOTS-c improved insulin sensitivity, protected against age-related insulin resistance and enhanced physical capacity in aged mice. Circulating levels decline with age in humans. Published proteomic work links MOTS-c to skeletal-muscle metabolic adaptation and exercise-response gene programmes.

Published clinical evidence

Selected peer-reviewed studies and outcome trials referenced in the MOTS-c literature. Sources listed for orientation; full papers via PubMed / journal DOI.

MOTS-c improves insulin sensitivity (mouse)
Cell Metabolism · 2015 (Lee et al.)
Original characterisation of MOTS-c — systemic administration prevented diet-induced obesity and improved insulin sensitivity via AMPK activation in a rodent model.
MOTS-c enhances physical capacity in aged mice
Nature Communications · 2021
Late-life MOTS-c administration improved treadmill capacity, grip strength and metabolic markers in aged mice.
Circulating MOTS-c and age in humans
Journal of Gerontology · 2019
Cross-sectional human data showing progressive decline of circulating MOTS-c with chronological age.
MOTS-c and skeletal-muscle exercise adaptation
American Journal of Physiology · 2020
MOTS-c expression rose in response to acute exercise and modulated muscle transcriptional programmes for metabolic adaptation.

Verified test batches — download COAs

Independent third-party Certificates of Analysis for recent MOTS-c batches. Click any COA to open or download the full lab report — verify each result at www.janoshik.com/verify.

BatchLabPurityCOA

aura004 · #72762

HPLC + MS · 2025-07-28

Janoshik Analytical99.5%Download →

MS10/2025-05 · #65126

HPLC + MS · 2025-05-15

Janoshik Analytical99.8%Download →

Verify any COA at www.janoshik.com/verify using the unique key printed on the report. What is Janoshik?

Why researchers buy from Regena

HPLC ≥99% purity

Every batch independently tested. Mass spectrometry verification on every research compound. COAs on request.

10-vial kits, properly sealed

Lyophilized peptide, rubber-stoppered amber vials, batch-coded. Stable for shipping; cold storage on arrival.

Germany · USA · China hubs

Tracked delivery from the best hub for your destination and available stock. Discreet, plain packaging.

Secure SEPA bank transfer

Encrypted checkout, verified IBAN. No card details stored. Card payment links available on request.

How ordering works

1
Pick your MOTS-c kit above
Each kit contains 10 vials. Choose your strength — bigger vials give you a lower €/mg.
2
Secure checkout in under 2 minutes
Add to cart, fill in shipping, get your IBAN and order reference instantly.
3
Pay by bank transfer (or card on request)
Bank transfer is fastest and fee-free. Need a card? Message us on WhatsApp and we'll send a payment link.
4
We ship within 24 hours
You get a tracking number by email + WhatsApp. EU delivery 5–18 business days. COA included on request.

Frequently asked questions

Research-use disclaimer

Information on this page is provided for educational and scientific reference purposes only. MOTS-c is a research compound intended for in-vitro laboratory investigation by qualified professionals. Nothing here constitutes medical advice, dosing guidance or a recommendation for human or veterinary use. Half-life and mechanism descriptions reflect published literature approximations.

Need protocol guidance?

Book a free 20-minute consultation — we'll map MOTS-c and adjacent reference compounds to your research goals.

Book consultation →

Add a solvent

Bacteriostatic Water
Kit of 10 × 10 ml vials · Standard solvent for most peptides
€149.00
Acetic Acid Kit
Kit of 10 × 3 ml vials (liquid) · For peptides that stay cloudy in BAC water
€149.00

Worldwide delivery from Fuengirola

Regena Peptides is based in Fuengirola, Spain and ships HPLC-verified research compounds worldwide — Europe, the UK and the USA — from our Germany, USA and China hubs, 5–18 business days from tracking.

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Free: Peptide Storage & Reconstitution Guide

30-page PDF — vial handling, sterile reconstitution, dosing math, cold-chain storage. Plus a daily research insight email from the lab.

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Keep reading

MOTS-c — shipped to research hubs worldwide

Same HPLC-verified MOTS-c batch, same COA — tracked delivery to laboratories and independent researchers across Europe, the UK, the USA and beyond. Pick a hub for local shipping window and currency notes.

View every research hub we ship to →Browse the full peptide library Site index

Customer reviews

What researchers say about MOTS-c

Share your experience

Your review helps other researchers evaluate MOTS-c. We publish every real review — positive or critical — after a quick moderation pass to filter spam and PII.

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Cite this reference

Researching MOTS-c?

Copy a ready-made citation or HTML link. Backlinks from research blogs, lab wikis and biohacker communities help others find verified peptide sources.

Regena Peptides. (2026-10-23). MOTS-c — HPLC-verified research peptide. https://regena.app/peptides/mots-c

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Head-to-head research comparisons

Deciding between compounds? Compare mechanism, receptor profile, half-life and handling side-by-side.

MOTS-c vs SS-31: Research Comparison | Regena Peptides