Substance P (1-4)

Also known as SP(1-4)

An N-terminal tetrapeptide fragment of Substance P, SP(1-4) is studied for its biological activities independent of the classical NK-1 receptor.

Length: 4 amino acids
Half-life: Not well characterised
Mechanism: This N-terminal fragment of Substance P interacts with cellular targets distinct from the NK-1 receptor, modulating specific signaling pathways.
Studied in: It is investigated in cellular models to understand the non-tachykinin activities of Substance P fragments, including their effects on specific cell types.

About Substance P (1-4)

Substance P (1-4) is a tetrapeptide, Arg-Pro-Lys-Pro, that constitutes the N-terminal sequence of the full 11-amino acid tachykinin, Substance P. Unlike the full-length peptide, whose canonical actions are mediated by the neurokinin-1 (NK-1) receptor, this fragment does not bind with high affinity to tachykinin receptors. Instead, it is understood to have its own distinct biological profile and cellular targets.

Research into Substance P (1-4) focuses on its non-classical, non-tachykinin functions. In laboratory studies, it is used to investigate cellular mechanisms that are modulated by N-terminal fragments of Substance P. These lines of inquiry are separate from the study of pain and inflammation associated with full-length Substance P and NK-1 receptor activation, providing a tool to explore alternative signaling roles.

Laboratory notes

This fragment lacks the C-terminal sequence required for high-affinity binding to and activation of the NK-1 receptor.
Biological effects are highly concentration-dependent and cell-type specific.
Experiments often use full-length Substance P and NK-1 antagonists as controls to differentiate fragment-specific effects.

Storage and reconstitution basics: storage guide.

Questions about Substance P (1-4)

Does Substance P (1-4) activate the NK-1 receptor?

No, it lacks the necessary C-terminal domain and does not effectively bind to or activate the NK-1 receptor. Its activities are considered non-tachykininergic.

What is the purpose of studying this specific fragment?

It allows researchers to investigate whether the N-terminal portion of Substance P has intrinsic biological activities that are separate from the well-known functions of the full-length peptide.

What is the sequence of this peptide?

The amino acid sequence is Arg-Pro-Lys-Pro, corresponding to the first four residues of Substance P.

Is Substance P (1-4) for human use?

No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.

Related research peptides

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