Galanin Message-Associated Peptide (GMAP)

Co-processed from the galanin precursor, GMAP is a peptide with observed antimicrobial activity in vitro, studied alongside galanin in neurological models.

Length: 59 or 60 amino acids (human)
Half-life: Not well characterised
Mechanism: GMAP is co-synthesized and co-secreted with galanin from the preprogalanin precursor, but its specific receptor and primary mechanism of action remain poorly defined.
Studied in: It is studied in laboratory settings for its potential antimicrobial properties and its functional relationship with galanin in neuronal systems.

About Galanin Message-Associated Peptide (GMAP)

Galanin message-associated peptide (GMAP) is a peptide that results from the post-translational processing of the preprogalanin protein precursor, the same precursor that yields galanin. This co-synthesis and co-release suggest a related or synergistic function, though the precise biological role of GMAP is less understood than that of galanin. It is a highly conserved peptide across many species.

Initial research identified GMAP's ability to inhibit the growth of various bacteria in vitro, suggesting a potential role in innate immunity within the nervous system. Further investigations in cellular models explore its influence on neuronal excitability and its interaction with galanin signaling pathways. However, a dedicated, high-affinity receptor for GMAP has not yet been definitively identified.

Laboratory notes

GMAP contains multiple cysteine residues and is presumed to form intramolecular disulfide bonds, which may be critical for its structure and function.
When reconstituting, gentle vortexing is recommended to ensure complete dissolution without damaging peptide structure.
Research protocols may require reduced and non-reduced sample preparation to study the impact of disulfide bonding on its activity.

Storage and reconstitution basics: storage guide.

Questions about Galanin Message-Associated Peptide (GMAP)

What is the origin of GMAP?

GMAP is derived from the same precursor protein, preprogalanin, as the neuropeptide galanin. They are often co-expressed and co-released from the same neurons.

Does GMAP have a known receptor?

A specific, dedicated receptor for GMAP has not been conclusively identified, and its exact signaling mechanism is an active area of research.

What are the main areas of in vitro research for GMAP?

Laboratory studies primarily focus on its antimicrobial properties against various microbes and its potential modulatory effects on neuronal function, often in concert with galanin.

Is Galanin Message-Associated Peptide (GMAP) for human use?

No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.

Related research peptides

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