Cognitive · Neuropeptide fragment
Galanin (1-16)
Also known as GAL(1-16)
A 16-amino acid N-terminal fragment of galanin, GAL(1-16) is a preferential agonist for the GALR2 receptor subtype used in neuroscience research.
- Length
- 16 amino acids
- Half-life
- Not well characterised
- Mechanism
- This N-terminal fragment of galanin preferentially binds to and activates the GALR2 receptor subtype over GALR1.
- Studied in
- Laboratory studies investigate its role in neurogenesis, synaptic plasticity, and cellular responses to excitotoxic stress in neuronal models.
About Galanin (1-16)
Galanin (1-16) is the N-terminal fragment of the full-length galanin neuropeptide. Unlike the full peptide which shows high affinity for all three galanin receptor subtypes (GALR1, GALR2, GALR3), this 16-amino acid sequence demonstrates preferential agonist activity at the GALR2 subtype. This specificity makes it a valuable tool for differentiating the physiological roles of GALR1 and GALR2 in laboratory models.
In vitro research often employs Galanin (1-16) to explore cellular pathways mediated by GALR2 activation. These include studies on neurite outgrowth in primary neuronal cultures, modulation of neurotransmitter release, and the regulation of ion channel activity. Its selective action allows for precise investigation of receptor-specific signaling cascades in isolated tissues and cell lines.
Laboratory notes
- Galanin (1-16) is highly soluble in aqueous solutions like sterile water or phosphate-buffered saline (PBS).
- Due to its peptide nature, store reconstituted solutions at 2-8°C for short-term use and aliquot for long-term storage at -20°C or colder to prevent degradation.
- The fragment's activity is highly dependent on receptor expression levels in the chosen cell model, which should be verified.
Storage and reconstitution basics: storage guide.
Questions about Galanin (1-16)
What is the primary difference between Galanin (1-16) and full-length Galanin?
Galanin (1-16) is an N-terminal fragment that acts as a preferential agonist for the GALR2 receptor, whereas full-length Galanin interacts with all three receptor subtypes (GALR1, GALR2, GALR3).
Which receptor does Galanin (1-16) primarily interact with?
It is a selective agonist for the galanin receptor 2 (GALR2), making it useful for studying the specific functions of this receptor subtype in laboratory settings.
What is the molecular composition of Galanin (1-16)?
It is a peptide composed of the first 16 amino acids from the N-terminus of the parent galanin molecule.
Is Galanin (1-16) for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.