Hormone · Modified Heptapeptide Analogue
A-71623
A-71623 is a selective and potent CCK1R agonist used in research to study gut motility, pancreatic function, and satiety control mechanisms.
- Length
- 7 amino acids
- Half-life
- Not well characterised
- Mechanism
- A-71623 is a potent and highly selective agonist for the cholecystokinin receptor subtype 1 (CCK1R), formerly known as CCK-A.
- Studied in
- It is employed in gastroenterology and neuroscience research to investigate the role of CCK1R in processes like gallbladder contraction, pancreatic secretion, and satiety signaling.
About A-71623
A-71623 is a synthetic heptapeptide analogue designed for high potency and selectivity at the cholecystokinin 1 receptor (CCK1R). It incorporates unnatural amino acids and modifications to enhance its binding affinity and metabolic stability compared to the endogenous ligand, cholecystokinin (CCK). Its structure allows it to discriminate effectively between CCK1R and the related CCK2R.
The CCK1R is predominantly expressed in the gastrointestinal tract, including the gallbladder, pancreas, and pyloric sphincter, as well as in specific brain regions involved in feeding behavior. By selectively activating this receptor, A-71623 serves as a precise pharmacological probe in laboratory studies. Researchers use it to explore the downstream effects of CCK1R stimulation on smooth muscle contraction, enzyme secretion, and neuronal pathways that regulate food intake.
Laboratory notes
- Its high selectivity for CCK1R over CCK2R (often >1000-fold) makes it an excellent tool for differentiating the functions of these two receptor subtypes.
- Due to its peptide nature, it should be solubilized in a suitable buffer and stored frozen in aliquots to prevent degradation.
- When designing experiments, consider that the CCK1R can desensitize upon prolonged or high-concentration agonist exposure.
Storage and reconstitution basics: storage guide.
Questions about A-71623
What is the primary molecular target of A-71623?
A-71623 is a highly selective agonist for the cholecystokinin 1 receptor (CCK1R).
How does A-71623 differ from endogenous CCK?
It is a synthetic analogue with structural modifications that grant it greater selectivity for the CCK1R subtype and potentially increased stability.
What research fields utilize A-71623?
It is primarily used in GI physiology and neuroscience to study CCK1R-mediated functions like gallbladder contraction, pancreatic secretion, and satiety signaling.
Is A-71623 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.