Longevity · Tetrapeptide
Cortagen
A synthetic tetrapeptide (Ala-Glu-Asp-Pro) used in neuroscience research to investigate its effects on neuronal cell cultures and gene expression.
- Length
- 4 amino acids
- Half-life
- Not well characterised
- Mechanism
- The precise molecular mechanism is not fully defined, but literature suggests it may modulate the expression of genes involved in neuronal function and differentiation.
- Studied in
- It is used in neuroscience research to study its effects on neural cell cultures, including neuronal survival, differentiation, and response to stressors.
About Cortagen
Cortagen is a synthetic tetrapeptide with the amino acid sequence Alanine-Glutamic acid-Aspartic acid-Proline (Ala-Glu-Asp-Pro). It was designed based on analysis of peptides isolated from the cerebral cortex.
Its use in a laboratory setting is primarily focused on neuroscience research. In vitro studies examine its influence on the differentiation and survival of neuronal progenitor cells, its potential to protect cultured neurons from various forms of cytotoxic stress, and its ability to modulate the expression of specific brain-related genes.
Laboratory notes
- For neuronal cell culture experiments, add Cortagen to the medium at the desired final concentration after sterile filtration.
- Assess neuronal morphology and viability using standard techniques like immunocytochemistry for MAP2/Tuj1 or viability assays such as MTT or Calcein-AM.
- Lyophilised Cortagen should be stored at -20°C. Reconstituted solutions should be aliquoted to prevent freeze-thaw cycles and stored at -20°C or colder.
Storage and reconstitution basics: storage guide.
Questions about Cortagen
What is the amino acid sequence of Cortagen?
The sequence of the Cortagen tetrapeptide is Ala-Glu-Asp-Pro.
What type of laboratory models are used to study Cortagen?
Cortagen is primarily studied in in vitro models using cultured neuronal cells, such as primary cortical neurons or neuroblastoma cell lines.
Is Cortagen a naturally occurring peptide?
Cortagen is a synthetic peptide, designed based on peptides found in brain tissue, but it is not itself a direct tissue extract.
Is Cortagen for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.