Cosmetic · N-acetylated tetrapeptide
Acetyl Tetrapeptide-5
A synthetic tetrapeptide studied for its influence on microcirculation models and protein glycation in laboratory settings.
- Length
- 4 amino acids
- Half-life
- Not well characterised
- Mechanism
- Proposed mechanisms in vitro include inhibition of angiotensin I-converting enzyme (ACE) and interference with collagen glycation.
- Studied in
- Laboratory investigations examine its effects on microcirculation models, lymphatic drainage simulations, and protein glycation in tissue explants.
About Acetyl Tetrapeptide-5
Acetyl Tetrapeptide-5 is a synthetic peptide composed of four amino acids with the sequence Ac-Beta-Ala-His-Ser-His-OH. The N-terminal acetylation is intended to increase its stability against enzymatic degradation in experimental systems. Its structure has been investigated for potential bioactivity related to fluid balance and extracellular matrix integrity.
Research in laboratory settings explores its dual proposed mechanisms. One area of study involves its potential to inhibit ACE, which could influence local vascular permeability in tissue models. Another line of inquiry examines its ability to interfere with the glycation process, where sugars non-enzymatically cross-link with proteins like collagen, using in vitro assays.
Laboratory notes
- Readily soluble in water or standard aqueous buffers.
- Peptide solutions should be prepared fresh for quantitative assays to ensure concentration accuracy.
- Verify the purity and identity of the material using HPLC and MS analysis before beginning experiments.
Storage and reconstitution basics: storage guide.
Questions about Acetyl Tetrapeptide-5
What is the sequence of Acetyl Tetrapeptide-5?
The sequence is Acetyl-Beta-Alanine-Histidine-Serine-Histidine.
Why is the N-terminus acetylated?
N-terminal acetylation is a common modification in peptide chemistry to block degradation by aminopeptidases, potentially increasing its stability in cell culture media or assay buffers.
What is glycation in the context of this peptide's research?
In a laboratory context, glycation refers to the non-enzymatic reaction between reducing sugars and proteins, which can be simulated in vitro to study the potential inhibitory effects of compounds like Acetyl Tetrapeptide-5.
Is Acetyl Tetrapeptide-5 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.