Other · Conotoxin
alpha-Conotoxin ImI
Also known as α-CTx ImI
A 12-amino-acid peptide from cone snail venom that selectively blocks α7 nicotinic acetylcholine receptors, used as a tool in neuroscience research.
- Length
- 12 amino acids
- Half-life
- Not well characterised
- Mechanism
- alpha-Conotoxin ImI is a potent and selective competitive antagonist of the alpha7 nicotinic acetylcholine receptor (nAChR).
- Studied in
- Used in neuroscience as a specific pharmacological tool to block α7 nAChR function in studies of synaptic transmission, cognition, and inflammation.
About alpha-Conotoxin ImI
alpha-Conotoxin ImI is a 12-amino-acid neurotoxic peptide originally isolated from the venom of the cone snail Conus imperialis. Its structure is constrained by two disulfide bridges, which are essential for its high-affinity binding to its target.
This peptide functions as a potent and highly selective competitive antagonist of the homomeric alpha7 subtype of the nicotinic acetylcholine receptor (α7 nAChR). Due to this specificity, α-Conotoxin ImI is a valuable molecular probe in neurobiology. Researchers use it to isolate and study the physiological roles of α7 nAChRs in neuronal signaling, synaptic plasticity, and neuro-inflammatory processes in a variety of in vitro and ex vivo preparations.
Laboratory notes
- alpha-Conotoxin ImI is a potent neurotoxin. Always handle with appropriate laboratory safety precautions, including gloves and safety glasses, in a designated work area.
- Its activity is highly dependent on the correct formation of its two disulfide bonds. Reconstitute gently in buffer and avoid conditions that could reduce the disulfide bridges.
- To ensure receptor selectivity, it is advisable to run control experiments using cell lines or tissues lacking α7 nAChRs or by using another α7-specific ligand.
Storage and reconstitution basics: storage guide.
Questions about alpha-Conotoxin ImI
What is the specific molecular target of α-Conotoxin ImI?
It is a highly selective competitive antagonist for the alpha7 nicotinic acetylcholine receptor (α7 nAChR).
Where does this peptide originate?
It was originally identified in the venom of the marine cone snail, Conus imperialis. The product supplied is a synthetic equivalent.
Why is it used in neuroscience research?
Its high specificity for a single receptor subtype allows researchers to pharmacologically isolate the function of α7 nAChRs from other nicotinic receptor activity in experimental systems.
Is alpha-Conotoxin ImI for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.