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Research use only

Growth Hormone · Research kit

MK-677laboratory reference kit

aka Ibutamoren

MK-677 original Regena research vial
Kit of 10 vials

Oral ghrelin mimetic for long-duration GH/IGF-1 research.

Class
Oral ghrelin mimetic (non-peptide)
Half-life
~24 h
Kit
10 vials
Use
Research only

Available on request

Get a quote for MK-677

This compound isn't in the standard 10-vial kit catalog. Message us on WhatsApp and we'll quote pricing, mg options and lead time after reviewing current availability.

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Estimated delivery

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Questions about MK-677? Message us about available sizes and documentation.
Payment options at checkout. Choose Wise or Monzo card payment, or pay by SEPA / international bank transfer.
Tracked worldwide shipping. Discreet packaging from Germany, the USA or China; allow 5–18 business days after tracking is issued. Shipping details.
Batch test in progress. Ask us on WhatsApp for the current batch report, or browse the COA library.
Read our purity policy or contact us before ordering.

What is MK-677?

MK-677 (ibutamoren) is a non-peptide, orally bioavailable ghrelin receptor agonist used in long-duration GH/IGF-1 elevation research where parenteral dosing is impractical.

Mechanism of action

Orally bioavailable GHS-R agonist.

Primary research areas

Long-duration GH/IGF-1 elevation studies.

Research notes

  • Not a peptide; included for mechanistic completeness.

MK-677: expanded research context

MK-677 (ibutamoren) is an orally active, non-peptide small-molecule agonist of the ghrelin receptor (GHS-R1a), first described in the 1990s. Although not a peptide, it is studied alongside growth-hormone secretagogue peptides such as ipamorelin, GHRP-2 and GHRP-6 because it acts on the same receptor.

Research literature focuses on its effect on pulsatile growth-hormone and IGF-1 secretion, nitrogen balance, bone-turnover markers and sleep architecture in controlled clinical-research settings. Its long half-life relative to peptide secretagogues makes it a common comparator in GHS-R pharmacology.

Regena lists MK-677 as a research reference compound on a quote basis. Contact us to confirm current availability before ordering.

Published clinical evidence

Selected peer-reviewed studies and outcome trials referenced in the MK-677 literature. Sources listed for orientation; full papers via PubMed / journal DOI.

  • MK-677 and GH/IGF-1 in healthy older adults

    Annals of Internal Medicine · 2008

    Two-year randomised trial reporting sustained increases in GH pulsatility and IGF-1 alongside changes in fat-free mass markers.

  • Ibutamoren in diet-induced catabolism

    Journal of Clinical Endocrinology & Metabolism · 1998

    Study reporting reversal of diet-induced nitrogen wasting in healthy volunteers in a controlled research setting.

  • MK-677 and sleep architecture

    Neuroendocrinology · 1997

    Report of increased stage IV and REM sleep duration in young and older subjects.

  • Ghrelin receptor agonist pharmacology review

    Endocrine Reviews · 2000s

    Overview of GHS-R1a agonists including MK-677 and peptide secretagogues, and their comparative receptor pharmacology.

Third-party COA — testing in progress

Pending
The current MK-677 batch is with our independent laboratory (Janoshik Analytical / VidaLabs) for HPLC + Mass Spectrometry analysis. Published COAs for previously-tested compounds are available in our full COA library.

Need the batch-specific COA for your order? Email inforegenapeptides@gmail.com — we'll send it as soon as the lab returns the report (typically 5–10 business days after shipment).

Why researchers buy from Regena

HPLC ≥99% purity

Every batch independently tested. Mass spectrometry verification on every research compound. COAs on request.

10-vial kits, properly sealed

Lyophilized peptide, rubber-stoppered amber vials, batch-coded. Stable for shipping; cold storage on arrival.

Germany · USA · China hubs

Tracked delivery from the best hub for your destination and available stock. Discreet, plain packaging.

Secure SEPA bank transfer

Encrypted checkout, verified IBAN. No card details stored. Card payment links available on request.

How ordering works

  1. 1

    Pick your MK-677 kit above

    Each kit contains 10 vials. Choose your strength — bigger vials give you a lower €/mg.

  2. 2

    Secure checkout in under 2 minutes

    Add to cart, fill in shipping, get your IBAN and order reference instantly.

  3. 3

    Pay by bank transfer (or card on request)

    Bank transfer is fastest and fee-free. Need a card? Message us on WhatsApp and we'll send a payment link.

  4. 4

    We ship within 24 hours

    You get a tracking number by email + WhatsApp. EU delivery 5–18 business days. COA included on request.

Frequently asked questions

Research-use disclaimer

Information on this page is provided for educational and scientific reference purposes only. MK-677 is a research compound intended for in-vitro laboratory investigation by qualified professionals. Nothing here constitutes medical advice, dosing guidance or a recommendation for human or veterinary use. Half-life and mechanism descriptions reflect published literature approximations.

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Customer reviews

What researchers say about MK-677

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Cite this reference

Researching MK-677?

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Regena Peptides. (2026-10-22). MK-677 — HPLC-verified research peptide. https://regena.app/peptides/mk-677

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