Neuropeptide Y (13-36)

Also known as NPY(13–36); NPY13–36

A 24-residue C-terminal NPY fragment used to map receptor recognition and investigate Y2-preferring pharmacology.

Length: 24 amino acids
Half-life: Not well characterised
Mechanism: NPY(13–36) retains agonist activity at Y2 receptors while showing strongly reduced Y1 activity compared with intact NPY. Y2 signalling primarily involves Gi/o-dependent inhibition of adenylyl cyclase and modulation of neuronal ion channels.
Studied in: Y-receptor binding assays, recombinant signalling systems and isolated neuronal preparations use NPY(13–36) to examine C-terminal recognition and Y2-preferring activity.

About Neuropeptide Y (13-36)

Neuropeptide Y (13–36) is a C-terminal fragment of mature NPY, containing 24 residues rather than 36. For the human sequence, it is PAEDMARYYSALRHYINLITRQRY-NH2. It retains the amidated C-terminus but lacks the N-terminal segment involved in the intact pancreatic polypeptide fold. Studies of such truncated fragments helped establish that Y-receptor subtypes differ in their requirements for N-terminal sequence and overall peptide architecture.

Y2 receptors tolerate substantial N-terminal truncation more readily than Y1 receptors, making NPY(13–36) a useful structure–activity probe. Nevertheless, its potency should not be assumed to match intact NPY or shorter truncations such as NPY(3–36). Binding affinity and functional activity also need separate measurement. Because the fragment lacks much of the native fold, comparisons can reveal the contribution of C-terminal recognition without demonstrating that the truncated peptide reproduces every property of full-length NPY.

Laboratory notes

Confirm the starting residue, species sequence and terminal amidation to distinguish this reagent from other C-terminal NPY fragments.
The human sequence contains methionine; monitor oxidation when checking purity after storage or extended sample preparation.
Measure concentration–response relationships in the chosen receptor system rather than transferring potency estimates from intact NPY.

Storage and reconstitution basics: storage guide.

Questions about Neuropeptide Y (13-36)

Is NPY(13–36) a 13-residue peptide?

No. It contains original NPY residues 13 through 36 inclusive, giving a total of 24 amino acids.

Why is this fragment useful for receptor mapping?

It preserves the C-terminal receptor-recognition region while removing much of the N-terminal structure, allowing comparisons of subtype-specific sequence requirements.

Should NPY(13–36) be described as an established endogenous product?

Not without specific evidence. It is best described as a sequence-defined research fragment; its experimental activity does not itself establish endogenous formation.

Is Neuropeptide Y (13-36) for human use?

No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.

Related research peptides

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