Metabolic · Peptide fragment / Receptor antagonist
Amylin (8-37)
Also known as AC187
A fragment of the hormone amylin, Amylin (8-37) is a potent amylin receptor antagonist used in metabolic and neuroscience research.
- Length
- 30 amino acids
- Half-life
- Not well characterised, but likely short in plasma.
- Mechanism
- This N-terminally truncated fragment of human amylin acts as a competitive antagonist at the amylin receptor complex.
- Studied in
- It serves as a pharmacological tool to block endogenous amylin action in studies of glucoregulation, gastric emptying, and satiety signaling.
About Amylin (8-37)
Amylin (8-37) is a 30-amino acid peptide that represents a fragment of the full 37-amino acid hormone, human amylin. The fragment lacks the first seven N-terminal residues of the native peptide. This truncation is critical to its function as a receptor antagonist.
The peptide acts as a competitive antagonist at the amylin receptor, which is a complex of the calcitonin receptor co-expressed with a receptor activity-modifying protein (RAMP). By blocking the binding of endogenous amylin, it allows researchers to investigate the physiological roles of amylin signaling. It is used in in vitro and ex vivo models to probe the hormone's involvement in glucose homeostasis and appetite regulation.
Laboratory notes
- Human amylin sequences have a tendency to aggregate; handle solutions carefully and use freshly prepared dilutions.
- Reconstitution should be performed in sterile water or a weak acid buffer to improve solubility.
- Validate antagonist activity in a functional assay before use in complex experimental models.
Storage and reconstitution basics: storage guide.
Questions about Amylin (8-37)
What is the function of Amylin (8-37)?
It functions as a competitive antagonist, blocking the amylin receptor from being activated by the endogenous hormone amylin.
How does it differ from native amylin?
It is a truncated fragment, missing the first seven amino acids from the N-terminus of the full-length amylin hormone.
What is the amylin receptor?
It is a heterodimeric G protein-coupled receptor, composed of the calcitonin receptor plus a specific Receptor Activity-Modifying Protein (RAMP).
Is Amylin (8-37) for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.