Metabolic · Prohormone peptide
Glicentin
Also known as Proglucagon (1-69)
Glicentin is a 69-amino acid proglucagon-derived peptide containing the sequences for oxyntomodulin and glucagon, studied for its role in metabolism.
- Length
- 69 amino acids
- Half-life
- Not well characterised
- Mechanism
- Acts as a precursor to oxyntomodulin and glucagon, and may also exert some intrinsic activity at glucagon and GLP-1 receptors.
- Studied in
- Research models use glicentin to investigate proglucagon processing pathways and the integrated physiological effects of its constituent peptides in the gut and pancreas.
About Glicentin
Glicentin is a 69-amino-acid peptide that represents the 1-69 fragment of proglucagon. It is secreted by intestinal L-cells and contains the sequences for Glicentin-Related Polypeptide (GRPP), oxyntomodulin, and glucagon within its structure. The peptide undergoes further tissue-specific post-translational processing to yield smaller bioactive fragments.
In laboratory settings, glicentin is used as a tool to understand the complex processing of proglucagon. Researchers investigate its potential independent biological activities, as well as its function as a precursor molecule in studies of glucose homeostasis and intestinal physiology. Its presence in circulation makes it a relevant analyte in metabolic research.
Laboratory notes
- Due to its size and precursor nature, ensure complete solubilisation in an appropriate buffer before use in assays.
- Antibodies used for detection in immunoassays should be specific to glicentin and not cross-react with its processed products like glucagon or GLP-1.
- When studying its effects, consider that it can be cleaved into smaller, active peptides, which may confound the interpretation of results if not properly controlled.
Storage and reconstitution basics: storage guide.
Questions about Glicentin
What peptides are derived from glicentin?
Glicentin is processed to yield Glicentin-Related Polypeptide (GRPP), oxyntomodulin, and glucagon.
Where is glicentin primarily produced?
It is synthesized and secreted from the enteroendocrine L-cells of the small and large intestines.
Does glicentin have its own receptor?
While it can weakly activate GLP-1 and glucagon receptors, a dedicated, high-affinity receptor for glicentin itself has not been definitively identified.
Is Glicentin for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.