Metabolic · Pentapeptide
Enterostatin
Also known as VPDPR
A pentapeptide cleaved from procolipase, used in research to study the selective regulation of dietary fat intake and satiety signaling.
- Length
- 5 amino acids
- Half-life
- Not well characterised
- Mechanism
- This pentapeptide (Val-Pro-Asp-Pro-Arg) is the N-terminal propeptide of pancreatic colipase and is thought to modulate ingestive behavior, although its precise receptor remains under investigation.
- Studied in
- It is used in metabolic and neuroscience research to investigate the central and peripheral signaling pathways involved in the specific regulation of dietary fat intake.
About Enterostatin
Enterostatin is a pentapeptide with the sequence Val-Pro-Asp-Pro-Arg (VPDPR), which corresponds to the activation peptide of procolipase, a protein secreted by the pancreas. It is released in the gastrointestinal tract during the digestion of dietary fats. The peptide is absorbed and can act both peripherally and centrally after crossing the blood-brain barrier.
Although a specific high-affinity receptor has yet to be definitively identified, studies suggest enterostatin may interact with the F1 subunit of mitochondrial F0F1-ATP synthase or with opioid receptor systems. Its primary documented effect in laboratory models is the selective reduction of dietary fat intake without significantly altering total caloric consumption from carbohydrates or proteins. This makes it a unique tool for researchers investigating the neurobiology of macronutrient selection and the mechanisms governing fat appetite.
Laboratory notes
- The sequence Val-Pro-Asp-Pro-Arg (VPDPR) is conserved across many species, suggesting a fundamental biological role.
- The exact mechanism of action is still an active area of research, with several potential cellular targets proposed.
- Due to its small size, it is susceptible to peptidases; experimental design should account for potential degradation in biological media.
Storage and reconstitution basics: storage guide.
Questions about Enterostatin
What is the origin of Enterostatin?
It is a pentapeptide that is cleaved from the N-terminus of pancreatic procolipase during its activation in the gut.
What is the primary reported effect of Enterostatin in laboratory studies?
It has been shown to selectively reduce the intake of dietary fat in animal models.
Has a specific receptor for Enterostatin been identified?
The precise receptor and signaling pathway are not fully elucidated, though interactions with mitochondrial ATP synthase and opioid receptors have been proposed.
Is Enterostatin for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.