Hormone · Polypeptide hormone
Gastrin-17
Also known as Gastrin I, G-17
A 17-amino acid hormone used in laboratory settings to investigate gastric acid secretion and gastrointestinal mucosal cell growth.
- Length
- 17 amino acids
- Half-life
- 5-8 minutes (in plasma)
- Mechanism
- Stimulates gastric acid secretion by binding to the cholecystokinin B receptor (CCKBR) on parietal and enterochromaffin-like (ECL) cells.
- Studied in
- Used in gastrointestinal physiology research to probe mechanisms of acid secretion, mucosal cell proliferation, and CCKBR signaling pathways.
About Gastrin-17
Gastrin-17 (G-17) is a major circulating form of the peptide hormone gastrin, which is secreted by G-cells in the gastric antrum of the stomach. It is a linear peptide of 17 amino acids. Its secretion is primarily stimulated by the presence of peptides and amino acids in the gastric lumen.
The principal physiological role of G-17, and its main use in research, is the stimulation of gastric acid secretion. It accomplishes this by binding to the cholecystokinin B receptor (CCKBR) on both acid-producing parietal cells and histamine-releasing enterochromaffin-like (ECL) cells. It is also investigated for its trophic, or growth-promoting, effects on the gastrointestinal mucosa.
Laboratory notes
- Gastrin-17 is also known as Gastrin I (non-sulfated form); Gastrin II is an alternative form sulfated at the tyrosine residue.
- The peptide is relatively small and can adsorb to plastic and glass surfaces; use low-binding tubes.
- The C-terminal amide is critical for its biological activity.
Storage and reconstitution basics: storage guide.
Questions about Gastrin-17
What is the difference between Gastrin-17 and Gastrin-34?
Both are active forms of gastrin. Gastrin-17 (G-17) is a 17-amino acid peptide and the major form released after a meal, while Gastrin-34 (G-34) is a 34-amino acid peptide that circulates between meals. Both share the same active C-terminal sequence.
What is the main receptor for Gastrin-17?
Gastrin-17 mediates its effects primarily through the cholecystokinin B receptor (CCKBR), also known as the CCK2 receptor.
What cell types are direct targets of Gastrin-17 in the stomach?
In the gastric mucosa, Gastrin-17 directly targets parietal cells and enterochromaffin-like (ECL) cells to stimulate acid and histamine release, respectively.
Is Gastrin-17 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.