Hormone · Tripeptide
Glandokort
Also known as Glu-Asp-Arg
A tripeptide (Glu-Asp-Arg) studied in adrenocortical cell cultures for its effects on steroidogenic pathways and hormone synthesis.
- Length
- 3 amino acids
- Half-life
- Not well characterised
- Mechanism
- This peptide is investigated for its role in modulating the synthesis and secretion of steroid hormones in adrenal cortex cell line models.
- Studied in
- It is used in adrenocortical cell cultures to examine its effects on the expression of steroidogenic enzymes and cortisol production.
About Glandokort
Glandokort is a synthetic tripeptide with the sequence Glutamyl-Aspartyl-Arginine. This sequence is based on peptides isolated from the adrenal glands. The synthetic version offers a standardized reagent for laboratory investigation of adrenal cell function.
Research into its mechanism focuses on the regulation of the adrenal cortex. In-vitro studies use adrenocortical cell lines (e.g., H295R) to assess the peptide's impact on steroidogenesis. Experiments measure changes in hormone levels, such as cortisol and aldosterone, and the expression of key enzymes in the steroid synthesis pathway.
Laboratory notes
- For steroidogenesis assays, ensure the base medium is free of components that could interfere with hormone measurement by LC-MS or ELISA.
- Prepare stock solutions in ultrapure water and filter-sterilize before adding to cell cultures.
- As with all short peptides, confirm batch purity and concentration before initiating experiments.
Storage and reconstitution basics: storage guide.
Questions about Glandokort
What is the amino acid sequence for synthetic Glandokort?
The most commonly cited sequence for synthetic Glandokort is L-Glutamyl-L-Aspartyl-L-Arginine (Glu-Asp-Arg).
What cell model is appropriate for studying Glandokort?
The human adrenocortical carcinoma cell line NCI-H295R is a common model as it is capable of producing all major classes of steroid hormones.
How can its effects on hormone production be quantified?
Hormone levels (e.g., cortisol) in the cell culture supernatant can be accurately measured using liquid chromatography-mass spectrometry (LC-MS) or competitive ELISA kits.
Is Glandokort for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.