Metabolic · Neuropeptide
Neuromedin U
Also known as NMU
Neuromedin U is a highly conserved neuropeptide that acts on NMUR1 and NMUR2 receptors, studied for its role in energy balance and pain perception.
- Length
- 25 amino acids (human)
- Half-life
- Short, estimated in minutes
- Mechanism
- Functions as an agonist for two related G protein-coupled receptors, NMUR1 (peripheral) and NMUR2 (central).
- Studied in
- Laboratory models employ Neuromedin U to explore its diverse roles in regulating food intake, energy expenditure, circadian rhythms, and nociception.
About Neuromedin U
Neuromedin U (NMU) is a neuropeptide widely distributed in the central nervous system and peripheral tissues, particularly the gastrointestinal tract. The name "U" was given due to its potent contractile activity on the uterus, one of its first observed functions. It is highly conserved across species, indicating fundamental biological roles.
Research involving NMU focuses on its function as a signaling molecule for two specific G-protein coupled receptors, NMUR1 and NMUR2. It is a key tool in studies of energy homeostasis, where it has potent anorexigenic effects, and is also implicated in the regulation of circadian clocks, bone formation, and the stress response. Its role in peripheral inflammation and nociception is another active area of investigation.
Laboratory notes
- There are different endogenous forms (e.g., NMU-25 in humans, NMU-23 in rats); ensure the correct form is used for the species model under investigation.
- Reconstitute in sterile, nuclease-free water and aliquot to avoid repeated freeze-thaw cycles. Adsorption to plastic can be minimised with a carrier protein like 0.1% BSA.
- The distinct tissue distributions of its two receptors, NMUR1 and NMUR2, allow for targeted studies of central versus peripheral effects.
Storage and reconstitution basics: storage guide.
Questions about Neuromedin U
What does the 'U' in Neuromedin U stand for?
It stands for 'uterus,' as the peptide was first identified by its strong ability to contract uterine smooth muscle.
What are the main receptors for NMU?
NMU acts on two G protein-coupled receptors: NMUR1, found mainly in peripheral tissues, and NMUR2, found primarily in the brain.
What is a primary research area for NMU?
Its potent effect on reducing food intake (anorexigenic effect) makes it a significant focus in the study of appetite regulation and energy balance.
Is Neuromedin U for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.