Hormone · Somatostatin analog
Pasireotide
Also known as SOM230
A highly stable, multireceptor-targeted somatostatin analog with strong SSTR5 affinity, used for research on hormonal control and cell signaling.
- Length
- 6 amino acids
- Half-life
- ~11 hours (in plasma)
- Mechanism
- A cyclohexapeptide somatostatin analog, it acts as a high-affinity agonist at four of the five somatostatin receptor subtypes, with particularly high affinity for SSTR5.
- Studied in
- It is employed in endocrinology research to investigate signaling pathways where broad somatostatin receptor activation, especially SSTR5, is of interest.
About Pasireotide
Pasireotide is a synthetic cyclohexapeptide designed for enhanced stability and a broad somatostatin receptor (SSTR) binding profile. Its unique macrocyclic structure, which incorporates non-proteinogenic amino acids, results in a molecule highly resistant to enzymatic breakdown and possessing a long plasma half-life, making it a potent and durable agent in experimental models.
This compound is a reference compound with a clinical history. Distinct from older analogs, Pasireotide binds with high affinity to four of the five SSTR subtypes: SSTR1, SSTR2, SSTR3, and notably SSTR5. This multireceptor targeting, especially its potent activity at SSTR5, makes it a valuable tool for studying biological systems where SSTR5 plays a key role, such as in certain pituitary and neuroendocrine cell lines.
Laboratory notes
- Features a very broad binding profile, with high affinity for SSTR1, SSTR2, SSTR3, and SSTR5.
- Its affinity for SSTR5 is substantially higher than that of octreotide and lanreotide.
- Due to its unique cyclic structure, it has a significantly longer half-life compared to other octapeptide analogs.
Storage and reconstitution basics: storage guide.
Questions about Pasireotide
What makes Pasireotide's receptor profile unique?
Its key feature is its multireceptor binding combined with very high affinity for the SSTR5 subtype, a receptor that is not strongly targeted by octreotide or lanreotide.
What kind of structure does Pasireotide have?
It is a cyclohexapeptide, meaning it is a cyclic peptide composed of six amino acid residues.
Why is Pasireotide used in research?
It allows scientists to study the effects of activating a broad range of somatostatin receptors at once, and to specifically investigate the function of the SSTR5 receptor in various cell types.
Is Pasireotide for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.