Regenerative · Recombinant hormone
Sh-Polypeptide-7
Also known as Recombinant Human Growth Hormone (rHGH)
A recombinant 191-amino-acid polypeptide identical to human growth hormone, used as a reference compound in laboratory research.
- Length
- 191 amino acids
- Half-life
- Not well characterised in vitro; context-dependent.
- Mechanism
- Binds to the growth hormone receptor (GHR), initiating intracellular signaling cascades via the JAK/STAT pathway.
- Studied in
- Studied in various cell types in vitro to investigate its effects on cell proliferation, differentiation, and metabolism.
About Sh-Polypeptide-7
Sh-Polypeptide-7 is the INCI name for a recombinant polypeptide with the same 191-amino-acid sequence and structure as the primary 22 kDa isoform of human growth hormone (somatotropin). It is a single-chain globular protein stabilised by two disulfide bonds and is produced using recombinant DNA technology. This molecule is a reference compound with a clinical history.
Its primary mode of action involves binding to the growth hormone receptor (GHR) on the surface of target cells. This binding event induces receptor dimerization and initiates a cascade of intracellular signaling, most notably through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Research applications involve its use in cell culture to study gene expression and cellular processes like growth and metabolism.
Laboratory notes
- This is a large protein; gentle handling and swirling (not vigorous vortexing) during reconstitution is required to avoid denaturation.
- For consistent results in cell culture, use serum-free or low-serum media, as serum contains binding proteins that can modulate its activity.
- Its effects can be pleiotropic and highly cell-type specific, requiring careful experimental design and controls.
Storage and reconstitution basics: storage guide.
Questions about Sh-Polypeptide-7
What is the structure of sh-Polypeptide-7?
It is a single-chain protein composed of 191 amino acids, stabilised by two internal disulfide bonds, creating a distinct four-helix bundle structure.
What is the main signaling pathway activated by this polypeptide?
Binding to its receptor, GHR, predominantly activates the JAK2-STAT5 signaling pathway, leading to the transcription of target genes.
Is sh-Polypeptide-7 the same as human growth hormone?
Yes, it is a recombinant version with an amino acid sequence identical to the native 22-kDa isoform of human growth hormone.
Is Sh-Polypeptide-7 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.