Hormone · Melanocortin peptide
Beta-MSH
Also known as Beta-Melanocyte-Stimulating Hormone
A 22-amino acid pro-opiomelanocortin (POMC)-derived peptide used in laboratory research of melanogenesis and energy balance via MCR activation.
- Length
- 22 amino acids
- Half-life
- Approximately 7 minutes (in vitro, plasma)
- Mechanism
- Acts as an agonist of melanocortin receptors, primarily MC1R, MC3R, and MC4R, modulating cellular processes like melanogenesis and energy homeostasis.
- Studied in
- The peptide is utilized in cell culture and animal models to investigate melanocortin receptor signaling, pigmentation, and appetite regulation.
About Beta-MSH
Beta-Melanocyte-Stimulating Hormone (β-MSH) is an endogenous peptide hormone cleaved from the pro-opiomelanocortin (POMC) precursor protein. It is a member of the melanocortin family, which also includes ACTH and α- and γ-MSH. Its primary structure consists of 22 amino acids in humans.
In experimental systems, β-MSH demonstrates agonist activity at several melanocortin receptors (MCRs). Its binding affinity is highest for MC1R, making it a useful tool for studying melanogenesis in melanoma cell lines. It also interacts with MC3R and MC4R, allowing for laboratory investigations into its role in energy homeostasis and inflammation.
Laboratory notes
- β-MSH is susceptible to proteolytic degradation in serum-containing media.
- Lyophilised material should be stored at -20°C and protected from moisture.
- When reconstituting, gently swirl or pipette to dissolve; do not vortex, as this can cause aggregation.
Storage and reconstitution basics: storage guide.
Questions about Beta-MSH
What is the source of Beta-MSH?
Beta-MSH is an endogenous peptide produced through the enzymatic cleavage of its precursor protein, pro-opiomelanocortin (POMC), primarily in the pituitary gland.
Which receptors does Beta-MSH primarily target in vitro?
It is an agonist for several melanocortin receptors, showing notable activity at MC1R, MC3R, and MC4R, making it a tool for studying a range of physiological pathways.
How does Beta-MSH relate to α-MSH?
Both are derived from the same POMC precursor and share a core heptapeptide sequence, His-Phe-Arg-Trp, which is critical for their binding to melanocortin receptors. However, they differ in length and specific receptor affinities.
Is Beta-MSH for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.