Other · Disulphide-rich CART-derived neuropeptide fragment
CART (61-102)
Also known as CART(61–102); CARTp(61–102)
A 42-residue CART fragment retaining the conserved disulphide-rich core for comparative neuropeptide structure–activity research.
- Length
- 42 amino acids
- Half-life
- Not well characterised
- Mechanism
- CART (61-102) retains the disulphide-stabilised C-terminal domain implicated in CART-dependent neuronal signalling. Its direct receptor pharmacology is not firmly resolved, and findings involving proposed CART receptor GPR160 should not automatically be extrapolated from other CART fragments.
- Studied in
- Cell-based signalling assays, neuronal preparations and rodent circuit models examine CART (61-102) in structure–activity comparisons with longer CART peptides.
About CART (61-102)
CART (61-102) comprises 42 amino acids using the conventional short rat CART precursor numbering. Relative to CART (55-102), it lacks six N-terminal residues while retaining the cysteine-rich C-terminal region. Both fragments belong to the peptide family derived from the CARTPT precursor, whose transcript was characterised in the 1990s. The sequence designation alone does not establish whether a particular preparation represents an endogenous processing product or a synthetic fragment selected for structure–activity research.
The retained six cysteines allow formation of the three-disulphide framework characteristic of folded C-terminal CART peptides. This makes CART (61-102) useful for examining how N-terminal truncation influences signalling while preserving the core domain. Nevertheless, equivalent folding does not guarantee equivalent potency, stability or receptor engagement. Receptor-level interpretation remains cautious, particularly for GPR160: evidence obtained with another CART sequence must be distinguished from direct characterisation of the 61-102 fragment in the same experimental system.
Laboratory notes
- Check the exact N-terminal residue and analytical mass to distinguish this 42-residue fragment from CART (55-102).
- Use comparable folding and purity criteria for both fragments in truncation studies; different disulphide-isomer profiles can confound interpretation.
- Measure peptide integrity over the assay period when comparing fragments, since truncation may alter proteolytic susceptibility.
Storage and reconstitution basics: storage guide.
Questions about CART (61-102)
How does CART (61-102) differ from CART (55-102)?
It is shorter by six N-terminal amino acids and contains 42 rather than 48 residues. The conserved cysteine-rich C-terminal domain remains present.
Can activity data for CART (55-102) be assigned to this fragment?
Not without experimental confirmation. Differences in N-terminal sequence can affect folding behaviour, degradation and signalling responses even when the disulphide-rich core is retained.
Does the fragment name confirm endogenous occurrence?
No. Residue numbering defines a sequence interval, not its biological provenance. Claims about endogenous processing require sequence-resolved evidence from biological material.
Is CART (61-102) for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.