Lanreotide

Also known as BIM 23014

A stable, cyclic octapeptide analog of somatostatin, Lanreotide is a broad-spectrum agonist at somatostatin receptors used in cellular research.

Length: 8 amino acids
Half-life: Not well characterised in vitro; long-acting in vivo
Mechanism: This cyclic octapeptide acts as a somatostatin analog with a broader binding profile, showing high affinity for receptors SSTR2 and SSTR5 and moderate affinity for SSTR3/4.
Studied in: It is used in cellular and molecular biology to study the effects of sustained, broad-spectrum somatostatin receptor activation on cell proliferation and hormone secretion.

About Lanreotide

Lanreotide is a synthetic, cyclic octapeptide analog of somatostatin. Similar to other synthetic analogs like octreotide, its structure includes a D-amino acid (D-Tryptophan) and is cyclized to enhance stability and prolong its activity compared to the native hormone. Its distinct sequence gives it a unique receptor binding profile.

This compound is a reference compound with a clinical history. Unlike the more selective octreotide, lanreotide binds with high affinity to somatostatin receptor subtypes SSTR2 and SSTR5, and also shows moderate affinity for SSTR3 and SSTR4. This broader profile makes it a useful tool for investigating the collective effects of activating multiple somatostatin receptors simultaneously in various cancer cell lines and primary cell culture systems.

Laboratory notes

Possesses a broader SSTR binding profile than octreotide, engaging SSTR2, 3, 4, and 5.
The presence of D-Trp and a disulfide bridge contributes to its high stability against enzymatic cleavage.
In research, it is often compared with subtype-selective agonists to delineate the roles of individual SSTRs.

Storage and reconstitution basics: storage guide.

Questions about Lanreotide

What is the main difference between Lanreotide and Octreotide?

The primary difference is their receptor binding profile. Lanreotide is a broader-spectrum agonist, binding to SSTR2, 3, 4, and 5, while Octreotide is more selective for SSTR2 and SSTR5.

Is Lanreotide an agonist or antagonist?

It is an agonist, meaning it activates somatostatin receptors upon binding.

What is the structure of Lanreotide?

It is a cyclic octapeptide containing a disulfide bond, with the sequence (3-Nal)-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2.

Is Lanreotide for human use?

No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.

Related research peptides

All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.