Leptin (116-130)

Also known as Leptin Fragment 116-130

Leptin (116-130) is a 15-amino acid fragment of the leptin hormone, used in research to study its potential role in angiogenesis.

Length: 15 amino acids
Half-life: Not well characterised
Mechanism: Believed to be an active fragment of the full-length leptin protein, potentially involved in modulating angiogenesis or other specific leptin-mediated functions.
Studied in: Investigated in cell biology and angiogenesis research to determine if it recapitulates specific effects of the parent leptin protein, such as endothelial cell proliferation.

About Leptin (116-130)

Leptin (116-130) is a small peptide fragment corresponding to amino acid residues 116 to 130 of the full-length, 167-amino acid leptin protein. This specific sequence has been isolated and synthesized for research purposes to investigate whether it constitutes a functionally active domain of the parent hormone. The full leptin protein is a key adipokine involved in regulating energy balance.

Laboratory studies have focused on the potential pro-angiogenic properties of this fragment. In vitro experiments using endothelial cell cultures, such as HUVECs, examine its effects on cell migration, proliferation, and tube formation. This research aims to understand if specific functions of leptin can be attributed to smaller, discrete regions of the protein, which could inform studies on neovascularization.

Laboratory notes

This is a small fragment and may not possess all the activities of the full-length leptin protein; use full-length leptin as a positive control.
The biological activity and receptor interactions of this fragment are not as well defined as the parent protein.
Ensure high purity of the peptide, as trace contaminants could produce confounding results in sensitive cell-based assays.

Storage and reconstitution basics: storage guide.

Questions about Leptin (116-130)

Does this fragment activate the leptin receptor (Ob-R)?

The exact mechanism is an area of active research. It is hypothesized to interact with components of the leptin signalling pathway, but its binding affinity may differ significantly from full-length leptin.

What is the main research application for this peptide?

It is primarily used in in vitro models of angiogenesis to study its direct effects on endothelial cells, independent of the complex structure of the full leptin protein.

Does this fragment have the same satiety effects as full-length leptin?

There is limited evidence to suggest this fragment crosses the blood-brain barrier or has the same central effects on appetite as the full leptin protein.

Is Leptin (116-130) for human use?

No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.

Related research peptides

All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.