Metabolic · Polypeptide Hormone
Pancreatic Polypeptide
Also known as PP
A 36-amino acid hormone from the PP-fold family that targets the Y4 receptor, used in research on gastrointestinal and metabolic regulation.
- Length
- 36 amino acids
- Half-life
- Approximately 5-7 minutes in human plasma
- Mechanism
- It primarily acts as an agonist for the neuropeptide Y receptor Y4 (NPY4R), modulating gastrointestinal and metabolic functions.
- Studied in
- In vitro studies use this peptide to explore signaling pathways related to gastric emptying, pancreatic secretion, and energy homeostasis.
About Pancreatic Polypeptide
Pancreatic Polypeptide (PP) is a 36-residue hormone secreted by the pancreas. It shares a common tertiary structure, the PP-fold, with Neuropeptide Y (NPY) and Peptide YY (PYY), which consists of an alpha-helix packed against a polyproline helix. This structural motif is crucial for receptor interaction and biological function.
The peptide's primary receptor target is the G protein-coupled Y4 receptor, with lower affinity for Y1 and Y5 receptors. Activation of Y4R in laboratory models is associated with the inhibition of pancreatic exocrine secretion, slowed gastric emptying, and effects on hepatic glucose output. These properties make it a tool for studying the complex interplay of gut-brain axis signaling in metabolic control.
Laboratory notes
- Reconstitute in sterile, distilled water or a slightly acidic buffer for optimal solubility.
- The C-terminal tyrosinamide is critical for high-affinity binding to the Y4 receptor.
- Due to its short plasma half-life, in vivo studies often employ continuous infusion or stabilized analogues to observe sustained effects.
Storage and reconstitution basics: storage guide.
Questions about Pancreatic Polypeptide
What is the relationship between Pancreatic Polypeptide and NPY?
Both are members of the pancreatic polypeptide-fold (PP-fold) family of peptides and share structural homology, but they exhibit distinct receptor selectivity, with PP preferentially binding the Y4 receptor.
What is the source of this peptide?
This product is a synthetically manufactured peptide, ensuring high purity and batch-to-batch consistency for research applications.
Is this product sterile?
The lyophilised powder is provided non-sterile. For cell culture experiments, it should be reconstituted in sterile buffer and filtered through a 0.22 µm filter.
Is Pancreatic Polypeptide for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.