Hormone · Bombesin-like peptide
Neuromedin B
Also known as NMB
Neuromedin B is a bombesin family decapeptide that acts on the NMB receptor, studied for its effects on metabolism and gastrointestinal processes.
- Length
- 10 amino acids (mammalian)
- Half-life
- Very short, <2 minutes in plasma
- Mechanism
- Binds with high affinity to its specific G protein-coupled receptor, the Neuromedin B receptor (NMBR or BB1).
- Studied in
- Laboratory studies use NMB to investigate its roles in thermoregulation, thyroid hormone secretion, cell proliferation, and gastrointestinal function.
About Neuromedin B
Neuromedin B (NMB) is a 10-amino-acid peptide belonging to the bombesin-like peptide family. It was originally isolated from porcine spinal cord and is found throughout the central and peripheral nervous systems, as well as in the gastrointestinal tract. NMB functions as a neurotransmitter and a local hormone.
As a research compound, NMB is used to probe the function of the Neuromedin B receptor (NMBR), which is distinct from the Gastrin-Releasing Peptide receptor (GRPR). Its application in experimental models helps elucidate its involvement in regulating thyrotropin secretion from the pituitary, controlling body temperature, and modulating gut motility. It is also investigated as a potential growth factor in certain cell types.
Laboratory notes
- NMB has a very short biological half-life, which should be accounted for in experimental design.
- It is structurally related to Gastrin-Releasing Peptide (GRP) but shows high selectivity for its own receptor, NMBR (BB1), over the GRP receptor (BB2).
- For in vitro assays, use a carrier protein like BSA (0.1%) in buffers to prevent adsorption to plasticware.
Storage and reconstitution basics: storage guide.
Questions about Neuromedin B
To which peptide family does Neuromedin B belong?
It is a member of the bombesin-like peptide family, which also includes Gastrin-Releasing Peptide (GRP).
What is the primary receptor for NMB?
NMB preferentially binds to the Neuromedin B receptor (NMBR), also known as bombesin receptor subtype 1 (BB1).
What is a key difference between NMB and GRP?
Although structurally similar, they have distinct receptor preferences. NMB has high affinity for NMBR, while GRP has high affinity for the GRPR (BB2 receptor).
Is Neuromedin B for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.