Hormone · Peptide Antagonist
Cetrorelix
Also known as Cetrorelix Acetate
Cetrorelix is a synthetic decapeptide antagonist of the GnRH receptor used in research to control LH and FSH secretion. A reference compound.
- Length
- 10 amino acids
- Half-life
- Variable, can be over 50 hours in some models
- Mechanism
- It is a potent antagonist of the gonadotropin-releasing hormone (GnRH) receptor in the anterior pituitary.
- Studied in
- Cetrorelix is used in reproductive endocrinology research to reversibly suppress the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
About Cetrorelix
Cetrorelix is a synthetic decapeptide with multiple unnatural amino acids, engineered to act as an antagonist of the gonadotropin-releasing hormone (GnRH) receptor. As a reference compound with a clinical history, it is a well-characterised tool for reproductive research.
Its mechanism involves competitive binding to GnRH receptors on pituitary gonadotrophs, thereby preventing endogenous GnRH from stimulating the synthesis and release of LH and FSH. This provides researchers with a method for rapid, reversible chemical hypophysectomy in experimental models to study hormone-dependent processes.
Laboratory notes
- Contains several D-amino acids and other modifications, contributing to its high potency and long duration of action.
- Lyophilised peptide is typically supplied as an acetate salt; ensure correct molecular weight is used for molarity calculations.
- Reconstitution is often performed in sterile water; solutions should be used promptly or stored appropriately.
Storage and reconstitution basics: storage guide.
Questions about Cetrorelix
What is the function of Cetrorelix?
It acts as a GnRH antagonist, blocking the GnRH receptor in the pituitary gland to prevent the release of LH and FSH.
Is Cetrorelix an agonist or antagonist?
It is a direct and potent antagonist. Unlike GnRH agonists which cause an initial flare-up of hormones, antagonists induce immediate suppression.
What are unnatural amino acids?
These are amino acids not found among the 20 common proteinogenic amino acids. They are incorporated into synthetic peptides like Cetrorelix to enhance stability and receptor binding.
Is Cetrorelix for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.