Cognitive · Neuropeptide
Neuropeptide Y (NPY)
Also known as NPY
A 36-amino acid neuropeptide that activates Y receptors, studied in models of appetite regulation, stress response, and circadian rhythms.
- Length
- 36 amino acids
- Half-life
- Approximately 8-10 minutes in human plasma
- Mechanism
- NPY exerts its effects by activating a family of G protein-coupled receptors known as Y receptors (Y1-Y6).
- Studied in
- Laboratory investigations focus on its role in appetite regulation, circadian rhythms, and responses to stress in various cellular and animal models.
About Neuropeptide Y (NPY)
Neuropeptide Y (NPY) is a 36-amino acid peptide belonging to the pancreatic polypeptide family, characterized by a specific tertiary structure known as the PP-fold. It is widely distributed throughout the central and peripheral nervous systems. Its structure includes a stable hairpin-like conformation, which is critical for its binding affinity to its target receptors.
The biological activities of NPY are mediated through its interaction with at least five distinct G protein-coupled Y receptor subtypes (Y1, Y2, Y4, Y5, Y6). Receptor binding initiates intracellular signaling cascades, primarily involving the inhibition of adenylyl cyclase and modulation of calcium channels. In research settings, NPY is used to study neuronal signaling pathways related to energy homeostasis and physiological stress responses.
Laboratory notes
- NPY is soluble in water or dilute acetic acid solutions.
- Store lyophilised powder at -20°C; after reconstitution, aliquot and store at -80°C to avoid repeated freeze-thaw cycles.
- The C-terminal amide is essential for its full biological activity at most Y receptor subtypes.
Storage and reconstitution basics: storage guide.
Questions about Neuropeptide Y (NPY)
What is the primary function of NPY in a research context?
In vitro and in vivo models use NPY to investigate its signaling pathways through Y receptors, particularly in studies of energy balance and neuronal excitability.
Is this material suitable for human use?
No, this product is a high-purity reagent sold strictly for laboratory research use only and is not intended for human or veterinary application.
What is the molecular weight of human NPY?
The molecular weight of human Neuropeptide Y is approximately 4271.7 g/mol.
Is Neuropeptide Y (NPY) for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.