Cardiovascular · Dual Agonist Peptide
Obinepitide
Also known as Z-1620
Obinepitide is a synthetic dual-acting peptide agonist for endothelin receptors and neprilysin, studied in models of cardiovascular regulation.
- Length
- 30 amino acids
- Half-life
- Not well characterised
- Mechanism
- Obinepitide acts as a dual agonist, binding to both endothelin (ETA/ETB) receptors and neprilysin (NEP) to potentiate natriuretic peptide activity.
- Studied in
- Research applications focus on its dual-action properties in models of cardiovascular function, particularly relating to vasodilation and natriuresis.
About Obinepitide
Obinepitide is a synthetic 30-amino acid peptide designed as a dual-acting vasopeptidase agent. Its structure allows it to interact with both the endothelin receptor system and the enzyme neprilysin (NEP). This dual mechanism was engineered to provide combined effects related to vasoconstriction and vasodilation pathways for study.
The molecule acts as an agonist for endothelin receptors ETA and ETB, while simultaneously interacting with neprilysin, the enzyme responsible for degrading natriuretic peptides. This dual function allows researchers to investigate the complex interplay between the endothelin and natriuretic peptide systems. In laboratory studies, it serves as a tool to explore integrated cardiovascular and renal control mechanisms.
Laboratory notes
- Obinepitide's dual activity profile requires careful selection of control groups to isolate effects related to endothelin agonism versus neprilysin interaction.
- Reconstitute with a suitable sterile solvent; assess solution stability for the specific experimental conditions before use.
- Due to its complex mechanism, results can be highly model-dependent; verify receptor expression and NEP activity in the chosen experimental system.
Storage and reconstitution basics: storage guide.
Questions about Obinepitide
What is unique about Obinepitide's mechanism?
Obinepitide is a dual-acting compound, simultaneously targeting endothelin receptors and interacting with neprilysin, allowing for the study of combined pathways.
Is Obinepitide an enzyme inhibitor or a receptor agonist?
It exhibits both functions, acting as an endothelin receptor agonist and interacting with the neprilysin enzyme.
Why is Obinepitide sold for research use only?
Regena products, including Obinepitide, are intended exclusively for in-vitro laboratory research and are not for human or animal consumption or administration.
Is Obinepitide for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.