Hormone · Pancreatic polypeptide-fold peptide; Y-receptor agonist
Peptide YY (1-36)
Also known as PYY(1–36); PYY1–36
Full-length, amidated PYY used to investigate Y-receptor signalling and enzymatic conversion to the N-terminally truncated form.
- Length
- 36 amino acids
- Half-life
- Not well characterised
- Mechanism
- PYY(1–36) activates several neuropeptide Y receptor subtypes, particularly Y1, Y2 and Y5, with activity depending on species and assay context. These receptors predominantly couple to Gi/o proteins, commonly reducing adenylyl cyclase activity and modulating ion-channel signalling.
- Studied in
- Recombinant Y-receptor assays, intestinal preparations and rodent gastrointestinal models study PYY(1–36) signalling, secretion and conversion to PYY(3–36).
About Peptide YY (1-36)
Peptide YY (1–36) is the full-length, 36-residue form of PYY, an amidated peptide first isolated from porcine intestine in 1980. Its name reflects tyrosine residues at both ends of the mature sequence. PYY belongs to the pancreatic polypeptide family alongside neuropeptide Y and pancreatic polypeptide. Intestinal enteroendocrine L cells are a major source, and the peptide adopts the characteristic pancreatic polypeptide fold.
The intact N-terminus distinguishes PYY(1–36) from PYY(3–36), which is generated by dipeptidyl peptidase-4 cleavage of the first two residues. This processing alters receptor preference: the full-length peptide has broader Y-receptor activity, whereas the truncated form favours Y2. Laboratory studies therefore distinguish direct receptor responses from responses influenced by enzymatic conversion. Sequence identity, species origin and C-terminal amidation are important specifications for binding assays and intestinal model systems.
Laboratory notes
- Check the species-specific sequence and C-terminal amidation before comparing material with published receptor data.
- In matrices containing dipeptidyl peptidase-4, monitor conversion to PYY(3–36) or include validated enzyme-control conditions.
- Use low-binding consumables and validate recovery at dilute assay concentrations to limit adsorption-related variability.
Storage and reconstitution basics: storage guide.
Questions about Peptide YY (1-36)
How does PYY(1–36) differ from PYY(3–36)?
PYY(1–36) retains the N-terminal Tyr-Pro pair. Its removal changes the receptor profile, with PYY(3–36) showing stronger preference for Y2.
Is PYY(1–36) a Y2-selective reagent?
No. It activates multiple Y-receptor subtypes, so receptor-specific controls are needed to attribute a response to Y2.
Why can assay incubation time affect the result?
Proteolytic processing can change the proportion of intact and truncated peptide during incubation, potentially altering the observed receptor response.
Is Peptide YY (1-36) for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.