Other · N-terminal somatostatin processing fragment
Somatostatin-28 (1-12)
Also known as SST-28(1–12); S-28(1–12)
N-terminal somatostatin-28 fragment studied in precursor processing, tissue localisation and peptide-detection assays.
- Length
- 12 amino acids
- Half-life
- Not well characterised
- Mechanism
- Somatostatin-28 (1-12) lacks the cyclic receptor-binding region present in somatostatin-14 and intact somatostatin-28. A specific receptor and reproducible signalling mechanism for the isolated fragment have not been firmly established; canonical somatostatin receptor agonism should not be assumed.
- Studied in
- Neuroendocrine tissue extracts, peptide-processing systems and immunochemical assays study this fragment as a product or marker of prosomatostatin processing.
About Somatostatin-28 (1-12)
Somatostatin-28 (1-12) is the linear N-terminal segment of somatostatin-28, with the sequence SANSNPAMAPRE. In the precursor-derived 28-residue peptide, this segment precedes an Arg-Lys pair and the C-terminal somatostatin-14 sequence. Cleavage and subsequent basic-residue trimming can generate the isolated dodecapeptide. Unlike somatostatin-14, it contains no cysteine residues and cannot form the intramolecular disulphide bridge that constrains the established somatostatin receptor-binding region. This structural distinction is central to interpreting its experimental role.
Research on this fragment primarily concerns the distribution and processing of somatostatin-related peptides rather than a well-defined receptor pharmacology. Immunochemical detection can reveal material containing the N-terminal somatostatin-28 epitope, but antibody recognition alone cannot distinguish the free fragment from larger related molecules. Chromatographic separation or mass spectrometry is therefore valuable for identity confirmation. Findings obtained with intact somatostatin-28 should not be transferred to this fragment without direct functional evidence.
Laboratory notes
- Check antibody cross-reactivity with intact somatostatin-28 and precursor-derived material before assigning fragment-specific immunoreactivity.
- Monitor methionine oxidation during storage and analysis, particularly when comparing chromatographic profiles.
- Use chromatographic separation or mass spectrometry to distinguish the free dodecapeptide from larger peptides sharing its sequence.
Storage and reconstitution basics: storage guide.
Questions about Somatostatin-28 (1-12)
Is this fragment equivalent to somatostatin-14?
No. It is a different, N-terminal segment and lacks the disulphide-constrained sequence of somatostatin-14.
Does it have an established somatostatin receptor subtype preference?
No firmly established subtype preference is available for this isolated fragment. Receptor activity requires direct experimental verification.
Why can an immunoassay overestimate the free fragment?
An antibody against its sequence may also recognise intact somatostatin-28 or larger precursor-derived molecules containing the same epitope.
Is Somatostatin-28 (1-12) for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.