Cosmetic · Synthetic Hexapeptide Amide
Acetyl Hexapeptide-51 Amide
A synthetic hexapeptide amide that mimics FOXO3a activity, used in cell culture to research DNA repair mechanisms and cellular stress responses.
- Length
- 6 amino acids
- Half-life
- Not well characterised
- Mechanism
- This peptide is designed to mimic the activity of Forkhead box O3a (FOXO3a), a transcription factor involved in cellular stress resistance and DNA repair pathways.
- Studied in
- It is used in cell culture models, particularly with keratinocytes or fibroblasts, to study cellular responses to genotoxic stress, such as UV radiation or oxidative damage.
About Acetyl Hexapeptide-51 Amide
Acetyl Hexapeptide-51 Amide is a synthetic peptide modified with N-terminal acetylation and C-terminal amidation for enhanced stability in research applications. Its structure was developed to mimic a specific domain of the Forkhead box O3a (FOXO3a) transcription factor, a protein central to regulating cellular longevity, stress resistance, and DNA maintenance.
In vitro research employs this peptide to investigate fundamental cellular defense mechanisms. Studies on human fibroblast or keratinocyte cell lines often involve inducing cellular damage with agents like UV radiation or hydrogen peroxide. The peptide is then used to explore its potential influence on DNA repair pathways, cell cycle regulation, and overall cell viability under stress.
Laboratory notes
- Its mechanism is linked to the FOXO3a transcription factor, which is involved in cellular resistance to oxidative stress.
- Commonly used in studies involving induced DNA damage (e.g., via UV radiation) on cell cultures like human epidermal keratinocytes.
- Experimental analysis often involves assays for DNA damage markers (e.g., γH2AX foci) and cell viability (e.g., MTT assay).
Storage and reconstitution basics: storage guide.
Questions about Acetyl Hexapeptide-51 Amide
What biological molecule does Acetyl Hexapeptide-51 Amide mimic?
It is designed to mimic the activity of the Forkhead box O3a (FOXO3a) protein, a key transcription factor involved in cellular stress response and longevity.
What is the function of the FOXO3a protein?
FOXO3a is a transcription factor that helps regulate the expression of genes involved in resistance to oxidative stress, metabolism, cell cycle arrest, and DNA repair.
How is this peptide studied in the lab?
It is typically applied to cell cultures (e.g., fibroblasts) that are then exposed to a stressor like UV light. Researchers then analyze markers of DNA damage and the activity of cellular repair systems to understand the peptide's effects.
Is Acetyl Hexapeptide-51 Amide for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.