Cosmetic · N-acetylated Tetrapeptide
Acetyl Tetrapeptide-40
Acetyl Tetrapeptide-40 is a synthetic peptide used in skin cell models to study its modulatory effects on inflammation and vasodilation pathways.
- Length
- 4 amino acids
- Half-life
- Not well characterised
- Mechanism
- Acetyl Tetrapeptide-40 is proposed to downregulate LL-37-induced pro-inflammatory cytokine release in keratinocyte cultures.
- Studied in
- This peptide is investigated in cell culture models of skin inflammation, particularly for its effects on chemokine production and immune cell recruitment signals.
About Acetyl Tetrapeptide-40
Acetyl Tetrapeptide-40 is a synthetic peptide with the sequence Acetyl-Thr-Gly-Ile-Arg-NH2. The N-terminal acetylation and C-terminal amidation are modifications intended to enhance its stability against enzymatic degradation in experimental systems. Its design is based on research into peptides that can modulate inflammatory responses in skin cells.
In vitro studies on human keratinocytes and endothelial cells use this peptide to examine its influence on inflammatory pathways. Specifically, research focuses on its ability to affect the expression of cathelicidin LL-37 and associated chemokines like CXCL8. These studies aim to clarify the peptide's potential role in mitigating specific inflammatory cascades relevant to dermatological research models.
Laboratory notes
- Experimental designs often involve pre-incubation with the peptide before introducing an inflammatory stimulus (e.g., LL-37) to keratinocyte cultures.
- Quantification of relevant cytokines (e.g., IL-6, IL-8/CXCL8) and chemokines via ELISA or qPCR are common endpoints in studies with this peptide.
- Solubility should be tested in the specific cell culture medium to be used; stock solutions are often prepared in sterile water.
Storage and reconstitution basics: storage guide.
Questions about Acetyl Tetrapeptide-40
What is the primary application of Acetyl Tetrapeptide-40 in a lab setting?
It is primarily used in in-vitro models, such as keratinocyte cultures, to investigate its effects on inflammatory signaling.
What common molecular target is associated with its mechanism?
It is studied for its ability to modulate the effects of the antimicrobial peptide LL-37 in skin cell models.
Why is this peptide acetylated?
The N-terminal acetylation is a common chemical modification used to increase the peptide's stability against degradation by aminopeptidases.
Is Acetyl Tetrapeptide-40 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.