Cosmetic · N-acetylated Tetrapeptide
Acetyl Tetrapeptide-11
Also known as Acetyl-Pro-Pro-Tyr-Leu
An acetylated tetrapeptide used in lab research to study the synthesis of Syndecan-1 and Collagen XVII and their roles in epidermal cohesion.
- Length
- 4 amino acids
- Half-life
- Not well characterised
- Mechanism
- This peptide is proposed to stimulate the synthesis of Syndecan-1 and Collagen XVII, two proteins essential for epidermal cohesion and adhesion at the dermal-epidermal junction.
- Studied in
- In vitro studies on keratinocyte and fibroblast co-cultures investigate its role in maintaining epidermal integrity and cell-cell communication.
About Acetyl Tetrapeptide-11
Acetyl Tetrapeptide-11 is a synthetic, N-acetylated peptide with the sequence Pro-Pro-Tyr-Leu. The acetylation at the N-terminus provides increased resistance to proteolytic breakdown. This peptide is designed for research into the structural and functional integrity of the epidermis.
Its primary application in laboratory settings is the study of the dermal-epidermal junction (DEJ). Research on human keratinocyte cultures has shown that the peptide can upregulate the expression of Syndecan-1, a transmembrane proteoglycan, and Collagen XVII, a key adhesion molecule. These studies aim to understand the molecular mechanisms that reinforce the connection between the epidermis and the dermis.
Laboratory notes
- Due to its focus on cell-cell adhesion, co-culture models of keratinocytes and fibroblasts provide a more relevant system than single-cell-type cultures.
- Immunofluorescence staining for Syndecan-1 and Collagen XVII is a common method to visualize the peptide's effects on protein localization at cell junctions.
- The proline-rich sequence may confer specific conformational properties; this can be analyzed using circular dichroism spectroscopy.
Storage and reconstitution basics: storage guide.
Questions about Acetyl Tetrapeptide-11
What are the key protein targets for Acetyl Tetrapeptide-11 in research?
The primary targets of study are Syndecan-1 and Collagen XVII, which are integral proteins for maintaining the structure and adhesion of the epidermis.
What is the purpose of acetylating this peptide?
N-terminal acetylation protects the peptide from degradation by exopeptidases, enhancing its stability and effective concentration in experimental systems.
What experimental model is most appropriate for studying this peptide?
Reconstituted human epidermis models or co-cultures of primary human keratinocytes and fibroblasts are ideal for investigating its effects on the dermal-epidermal junction.
Is Acetyl Tetrapeptide-11 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.