Cosmetic · Biomimetic Peptide
Acetyl Tetrapeptide-2
Also known as Thymulen 4
An acetylated tetrapeptide derived from thymopoietin, used in vitro to study its effects on epidermal cell function and matrix proteins.
- Length
- 4 amino acids
- Half-life
- Not well characterised
- Mechanism
- This peptide is a biomimetic of thymopoietin and is studied for its effects on epidermal cell differentiation and structural protein synthesis.
- Studied in
- In vitro studies focus on its influence on extracellular matrix components, such as collagen and elastin, in fibroblast and keratinocyte co-cultures.
About Acetyl Tetrapeptide-2
Acetyl Tetrapeptide-2 is a synthetic peptide containing the amino acid sequence Val-Tyr-Val-Glu (VYVE), N-terminally acetylated. This sequence is a fragment derived from the thymic hormone thymopoietin. The N-terminal acetylation is a common modification intended to increase the peptide's stability against enzymatic degradation in experimental systems.
In a laboratory context, this peptide is used to investigate cellular mechanisms related to skin biology. Researchers apply it to cultures of human dermal fibroblasts and keratinocytes to assess its impact on the expression and synthesis of key structural proteins. Assays may measure changes in elastin, collagen, and other extracellular matrix (ECM) components to understand its role in modulating cell behavior.
Laboratory notes
- The peptide is soluble in water. For cell culture, dissolve in sterile, phosphate-buffered saline (PBS).
- Confirm peptide concentration using a quantitative amino acid analysis or by weighing on a calibrated microbalance.
- Store lyophilised peptide at -20°C. Once reconstituted, short-term storage at 4°C is recommended; avoid freeze-thaw cycles.
Storage and reconstitution basics: storage guide.
Questions about Acetyl Tetrapeptide-2
What does 'biomimetic of thymopoietin' mean?
It means the peptide's amino acid sequence is designed to mimic a small, active region of the natural hormone thymopoietin, allowing it to be used as a tool to study similar cellular pathways in vitro.
What are its primary applications in research?
It is used as a cosmetic ingredient for research and development, specifically to study its effects on dermal fibroblast and keratinocyte function in cell culture models.
Is this peptide suitable for direct application?
No, this is a concentrated raw material for formulation into experimental preparations or for use in in vitro assays. It is not for direct application or human use.
Is Acetyl Tetrapeptide-2 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.