Cosmetic · Neuropeptide Mimetic
Acetyl Octapeptide-3
Also known as SNAP-8
An octapeptide analogue of SNAP-25, used in vitro to study its competitive interference with the neuronal SNARE complex formation.
- Length
- 8 amino acids
- Half-life
- Not well characterised
- Mechanism
- It is an analogue of the N-terminal end of SNAP-25 protein and is studied for its ability to interfere with SNARE complex formation in vitro.
- Studied in
- Research assays investigate its competitive inhibition of the SNARE protein complex assembly and subsequent effects on vesicle fusion in neuronal cell models.
About Acetyl Octapeptide-3
Acetyl Octapeptide-3 is a synthetic peptide designed as an elongated version of Acetyl Hexapeptide-8. Its sequence mimics the N-terminal portion of the synaptosomal-associated protein 25 (SNAP-25). The peptide is N-terminally acetylated to enhance its stability against aminopeptidase degradation in experimental media.
The research focus of this peptide is its interaction with the SNARE (Soluble NSF Attachment Protein Receptor) complex. In biochemical assays, it is investigated for its potential to compete with native SNAP-25 for a position in the SNARE complex, which is essential for neurotransmitter-containing vesicle fusion at the pre-synaptic membrane. This mechanism is studied in neuronal cell cultures to understand its influence on exocytosis.
Laboratory notes
- The peptide is highly soluble in water and standard biological buffers.
- For SNARE complex inhibition assays, co-incubation with recombinant SNARE proteins (syntaxin, VAMP, and SNAP-25) is a common method.
- Purity should be >98% by HPLC for reliable quantitative results in competitive binding assays.
Storage and reconstitution basics: storage guide.
Questions about Acetyl Octapeptide-3
How does this peptide relate to the SNARE complex?
It is a structural mimic of a component of the SNARE complex, SNAP-25. It is used in research to study how such mimics can competitively interfere with the assembly of this protein machinery, which is critical for vesicle fusion.
Is this the same as Acetyl Hexapeptide-8?
No, Acetyl Octapeptide-3 is an octapeptide (8 amino acids), representing an elongated version of the hexapeptide (6 amino acids). Both are studied for similar mechanisms related to the SNARE complex.
What is this product's intended use?
This is a cosmetic-grade peptide intended for laboratory research and development, and for use in in vitro experiments. It is not for therapeutic or human use.
Is Acetyl Octapeptide-3 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.