Cosmetic · Neuropeptide Mimetic
Pentapeptide-3
Also known as Vialox
A synthetic pentapeptide studied in vitro for its antagonistic activity at the nicotinic acetylcholine receptor (nAChR).
- Length
- 5 amino acids
- Half-life
- Not well characterised
- Mechanism
- It is studied as an antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR) at the post-synaptic membrane.
- Studied in
- In vitro research investigates its ability to block ion flow through the nAChR channel, thereby inhibiting acetylcholine-induced cation influx in relevant cell models.
About Pentapeptide-3
Pentapeptide-3 is a synthetic peptide with the amino acid sequence Gly-Pro-Arg-Pro-Ala (GPRPA). It is designed as a structural mimic of a component of waglerin-1, a peptide found in temple viper venom. The peptide is small and water-soluble, making it suitable for use in aqueous-based in vitro assay systems.
This peptide's mechanism of action is investigated in the context of neuromuscular signaling. It functions as a competitive antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR). In electrophysiology or ion flux assays, it is studied for its ability to reversibly block the receptor's ion channel, preventing depolarization of the post-synaptic membrane that would normally be induced by acetylcholine.
Laboratory notes
- The peptide is readily soluble in water and PBS.
- Activity can be assessed using electrophysiological patch-clamp techniques on cells expressing the muscle-type nAChR, or via calcium imaging with a fluorescent indicator.
- Store lyophilised peptide desiccated at -20°C. Reconstituted aqueous solutions should be stored at 4°C for short periods or frozen for long-term storage.
Storage and reconstitution basics: storage guide.
Questions about Pentapeptide-3
What is the origin of this peptide's design?
The amino acid sequence is based on a fragment of waglerin-1, a peptide from snake venom known to be a potent antagonist of the nicotinic acetylcholine receptor.
How does it work in a laboratory setting?
It is used as a research tool to block the nicotinic acetylcholine receptor in vitro, allowing scientists to study the consequences of inhibiting this specific signaling pathway in cell culture models.
Is this product safe for any type of administration?
No. This product is a chemical reagent intended strictly for laboratory and in vitro research. It is not for human or animal use.
Is Pentapeptide-3 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.