Cosmetic · N-acetylated Tetrapeptide
Acetyl Tetrapeptide-9
Also known as Acetyl-Gln-Asp-Val-His
An acetylated tetrapeptide studied for its interaction with lumican and its role in promoting organized collagen fibril assembly in tissue models.
- Length
- 4 amino acids
- Half-life
- Not well characterised
- Mechanism
- This peptide binds to lumican, a proteoglycan, promoting collagen fibril organization and stabilization within the extracellular matrix of in vitro models.
- Studied in
- Research focuses on its ability to enhance the biomechanical properties of engineered skin tissues by improving collagen fibrillogenesis and matrix density.
About Acetyl Tetrapeptide-9
Acetyl Tetrapeptide-9 is a synthetic peptide featuring an N-terminal acetyl group, which enhances its stability against enzymatic degradation. The sequence Gln-Asp-Val-His is designed to interact specifically with proteoglycans in the extracellular matrix (ECM). Its primary target for research is its effect on collagen fibril architecture.
Laboratory investigations utilize this peptide to study the process of collagen fibrillogenesis. In cultures of human dermal fibroblasts, Acetyl Tetrapeptide-9 has been shown to bind to the proteoglycan lumican, which in turn helps guide the assembly of individual collagen molecules into well-organized, functional fibrils. This interaction is studied for its role in maintaining ECM structural integrity.
Laboratory notes
- The N-terminal acetylation increases peptide stability, which should be considered when comparing its activity to non-acetylated counterparts.
- Electron microscopy (TEM) is a suitable technique to visually assess changes in collagen fibril diameter and organization in treated tissue explants.
- For binding assays, immobilize lumican and measure the binding affinity of Acetyl Tetrapeptide-9 using techniques like surface plasmon resonance (SPR).
Storage and reconstitution basics: storage guide.
Questions about Acetyl Tetrapeptide-9
What is the function of the acetyl group on Acetyl Tetrapeptide-9?
The N-terminal acetyl group protects the peptide from degradation by aminopeptidases, increasing its stability and bioavailability in cell culture environments.
What specific process does this peptide target in vitro?
It targets collagen fibrillogenesis, the process by which collagen molecules assemble into larger, organized fibrils, by interacting with the proteoglycan lumican.
How can the effects of Acetyl Tetrapeptide-9 be quantified?
Effects can be measured by analyzing collagen content with assays like the Sircol assay, or by imaging collagen fibril structure using transmission electron microscopy on treated 3D skin models.
Is Acetyl Tetrapeptide-9 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.