Cognitive · Opioid peptide
beta-Neoendorphin
Also known as β-Neoendorphin
A prodynorphin-derived opioid peptide, beta-Neoendorphin is a KOR agonist used in laboratory models to study central nervous system pathways.
- Length
- 9 amino acids
- Half-life
- Extremely short in plasma due to rapid enzymatic cleavage.
- Mechanism
- An endogenous nonapeptide that acts as a potent agonist at kappa-opioid receptors and to a lesser extent, mu- and delta-opioid receptors.
- Studied in
- It is used in neuroscience research to investigate pathways of nociception, reward, and neuroendocrine regulation.
About beta-Neoendorphin
beta-Neoendorphin is a nine-amino-acid peptide with the sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro, derived from the same prodynorphin precursor as alpha-Neoendorphin. It is structurally identical to alpha-Neoendorphin minus the C-terminal lysine residue. This small structural difference influences its receptor binding profile and biological activity.
Primarily acting as a kappa-opioid receptor (KOR) agonist, it displays less selectivity than dynorphin A, with some cross-reactivity at mu- and delta-opioid receptors. Its function is explored in in vitro receptor binding assays and in cellular models to understand the complexities of the endogenous opioid system.
Laboratory notes
- Solution stability is poor; prepare fresh solutions for each experiment.
- Handle with care to avoid contamination, as peptides are susceptible to microbial and enzymatic degradation.
- Confirm peptide identity and purity via mass spectrometry and HPLC before use in critical assays.
Storage and reconstitution basics: storage guide.
Questions about beta-Neoendorphin
How does beta-Neoendorphin differ from alpha-Neoendorphin?
beta-Neoendorphin is a nonapeptide, lacking the C-terminal lysine found in the decapeptide alpha-Neoendorphin.
Is this peptide selective for one receptor?
It is a potent kappa-opioid receptor agonist but also shows some activity at mu- and delta-opioid receptors.
What is its precursor protein?
Like other dynorphins, it is processed from the precursor protein prodynorphin.
Is beta-Neoendorphin for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.