Hormone · Peptide Antagonist
Degarelix
A long-acting synthetic decapeptide antagonist of the GnRH receptor, used in research to induce sustained chemical castration. A reference compound.
- Length
- 10 amino acids
- Half-life
- Forms a depot; effective half-life is 23-60 days
- Mechanism
- This third-generation GnRH antagonist binds competitively to pituitary GnRH receptors, suppressing gonadotropin and subsequent testosterone secretion.
- Studied in
- It is used in endocrinology and oncology research models to achieve sustained androgen deprivation for studying hormone-sensitive processes.
About Degarelix
Degarelix is a synthetic decapeptide GnRH antagonist incorporating five non-proteinogenic amino acids. It is engineered for high water solubility and the ability to form a gel-like depot upon subcutaneous administration in lab models, enabling sustained release. This molecule is a reference compound with a clinical history.
Its primary research use is as a tool for inducing rapid and profound suppression of the hypothalamic-pituitary-gonadal axis. By blocking GnRH receptors, it prevents LH and FSH release, leading to a sharp decline in gonadal steroid production. This makes it valuable for creating long-term chemical castration models for studying androgen-dependent diseases.
Laboratory notes
- The peptide is designed to precipitate at the administration site in vivo, forming a depot for slow release.
- Supplied as a powder for reconstitution; the specific diluent is critical for achieving the desired depot-forming properties.
- Due to its long-lasting effect, washout periods in crossover study designs must be extensive.
Storage and reconstitution basics: storage guide.
Questions about Degarelix
How does Degarelix differ from older GnRH antagonists?
Degarelix is a third-generation antagonist designed to have a lower histamine-releasing potential and to form a subcutaneous depot for prolonged action compared to earlier antagonists.
What is a 'depot' effect?
In this context, it means the peptide solution forms a gel-like solid upon administration in a lab animal, which then slowly releases the peptide over several weeks.
Does Degarelix cause a hormone flare?
No, as a GnRH antagonist, it causes immediate suppression of LH, FSH, and testosterone without the initial surge seen with GnRH agonists.
Is Degarelix for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.