Cosmetic · Lipopeptide
Palmitoyl Tripeptide-28
A synthetic lipopeptide combining a three-amino-acid sequence with palmitic acid, studied for its role in modulating extracellular matrix components.
- Length
- 3 amino acids (conjugated to palmitic acid)
- Half-life
- Not well characterised
- Mechanism
- Designed to interact with cellular pathways involved in extracellular matrix protein synthesis, such as transforming growth factor beta (TGF-β) signaling.
- Studied in
- Investigated in dermal fibroblast cultures and 3D skin models for its effects on the expression of extracellular matrix components like collagen.
About Palmitoyl Tripeptide-28
Palmitoyl Tripeptide-28 is a synthetic molecule that conjugates the tripeptide Arginyl-Cysteinyl-Asparagine to a palmitic acid moiety. The fatty acid chain is attached to improve peptide stability and facilitate interaction with cell membranes in experimental models. This lipidation is a common chemical strategy to enhance specific properties of short peptides for research applications.
This peptide is designed for research into pathways governing extracellular matrix (ECM) homeostasis. In laboratory settings using human dermal fibroblast cell cultures, it is used to study the modulation of key ECM proteins. Its mechanism is explored in the context of cell signaling cascades that regulate collagen and elastin synthesis.
Laboratory notes
- Due to its lipophilic nature, reconstitution may require a co-solvent like DMSO or ethanol before dilution in aqueous media.
- When used in cell culture, verify the final solvent concentration is not cytotoxic to the cells being studied.
- Filter sterilisation of reconstituted stock solutions using a 0.22 µm filter is recommended for cell-based applications.
Storage and reconstitution basics: storage guide.
Questions about Palmitoyl Tripeptide-28
What is the purpose of the palmitoyl group?
The palmitic acid chain increases the peptide's lipophilicity, which is intended to enhance its stability and interaction with the lipid bilayers of cells in experimental systems.
What is the peptide component of this molecule?
The peptide is a three-amino-acid sequence: Arginine-Cysteine-Asparagine.
What kind of in vitro models are used to study this peptide?
It is typically studied in 2D cultures of human dermal fibroblasts or more complex 3D reconstructed human skin equivalents to assess effects on gene and protein expression.
Is Palmitoyl Tripeptide-28 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.