Immune · Immunomodulatory tetrapeptide
Rigin
Rigin is a tetrapeptide (Gly-Gln-Pro-Arg) investigated for its immunomodulatory properties and effects on cytokine expression in vitro.
- Length
- 4 amino acids
- Half-life
- Not well characterised
- Mechanism
- Proposed to act in an immunomodulatory capacity, potentially influencing cytokine release from immune cells.
- Studied in
- Studied in cellular models for its potential role in modulating cytokine balance and immune cell activity, often in comparison to Tuftsin.
About Rigin
Rigin is a tetrapeptide with the amino acid sequence Glycyl-Glutaminyl-Prolyl-Arginine (GQPR). It corresponds to a four-amino-acid stretch found within the heavy chain of immunoglobulin G (IgG), similar to the immunomodulatory peptide Tuftsin. This shared origin has prompted comparative studies to delineate their respective activities.
Laboratory investigations focus on Rigin's immunomodulatory functions. It has been examined in cell culture systems for its effects on leukocyte function and its ability to influence the production of cytokines. It is considered a research peptide for exploring signaling pathways related to immune regulation, particularly those involving a balance of pro- and anti-inflammatory signals.
Laboratory notes
- The sequence Gly-Gln-Pro-Arg corresponds to residues 342-345 of the human IgG1 heavy chain constant region.
- The peptide is water soluble; prepare solutions fresh for use in cell culture experiments to ensure maximal activity.
- Often studied in parallel with Tuftsin to compare and contrast their effects on immune cells.
Storage and reconstitution basics: storage guide.
Questions about Rigin
How is Rigin related to Tuftsin?
Both are tetrapeptides derived from regions of the IgG heavy chain and are studied for their potential immunomodulatory properties.
What is the amino acid sequence of Rigin?
The sequence is Gly-Gln-Pro-Arg, or GQPR in single-letter code.
What is the primary research area for Rigin?
Its primary research area is immunology, specifically investigating its effects on cytokine production and the function of immune cells in vitro.
Is Rigin for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.