Thymopentin

Also known as TP-5

Thymopentin (TP-5) is a synthetic 5-amino acid peptide corresponding to the active site of thymopoietin, used in T-cell immunology research.

Length: 5 amino acids
Half-life: Very short, under 30 seconds in plasma.
Mechanism: Thymopentin corresponds to the active site of the thymus hormone thymopoietin and modulates lymphocyte differentiation and function.
Studied in: It is used in immunological research to study T-cell maturation, cytokine production in lymphocyte cultures, and the regulation of immune responses in vitro.

About Thymopentin

Thymopentin, also known as TP-5, is a synthetic pentapeptide with the amino acid sequence Arg-Lys-Asp-Val-Tyr. This sequence corresponds to amino acids 32-36 of the natural thymus hormone thymopoietin, and it is considered to be the active site of the parent molecule. Due to its small size and defined activity, it is a valuable tool for in vitro immunology studies.

The peptide's biological activity involves the modulation of the immune system, particularly influencing the differentiation and function of T-lymphocytes. In cell culture experiments, Thymopentin has been shown to affect the expression of T-cell surface markers, promote the maturation of precursor cells into functional T-cells, and regulate the production of various cytokines. It is a reference compound with a clinical history, allowing researchers to probe specific aspects of cell-mediated immunity in a controlled laboratory environment.

Laboratory notes

Thymopentin is readily soluble in water and standard cell culture media.
Due to an extremely short plasma half-life, its effects in vivo are transient unless administered via continuous infusion.
Assays using primary lymphocyte cultures should be carefully controlled for donor variability.

Storage and reconstitution basics: storage guide.

Questions about Thymopentin

What is the origin of Thymopentin's sequence?

Thymopentin is a synthetic peptide whose 5-amino acid sequence is identical to the biologically active site (residues 32-36) of the natural thymic hormone, thymopoietin.

What is the primary area of research for Thymopentin?

It is primarily used in immunology research to study the maturation, differentiation, and functional regulation of T-lymphocytes in vitro.

What does 'TP-5' stand for?

'TP-5' is a common abbreviation for Thymopentin, referencing its origin from Thymopoietin and its length of 5 amino acids.

Is Thymopentin for human use?

No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.

Related research peptides

All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.