Sauvagine

Sauvagine is a 40-amino acid peptide from frog skin that is a potent CRF receptor agonist, used to study stress and cardiovascular control systems.

Length: 40 amino acids
Half-life: Not well characterised
Mechanism: Serves as a potent agonist for corticotropin-releasing factor (CRF) receptors, showing a preference for the CRF2 subtype.
Studied in: Utilised in laboratory studies as a pharmacological tool to probe the function of CRF receptor systems, particularly in relation to cardiovascular regulation, stress response, and metabolism.

About Sauvagine

Sauvagine is a 40-amino-acid peptide originally isolated from the skin of the frog, Phyllomedusa sauvagei. It is structurally and functionally related to the urotensin-I family and mammalian corticotropin-releasing factor (CRF). This homology allows it to interact with CRF receptors in mammalian systems.

In research, sauvagine is a valuable pharmacological agent for investigating the CRF system. Due to its high affinity and potency, particularly at the CRF2 receptor, it is used to induce and study physiological responses such as hypotension, vasodilation, and changes in metabolic rate in experimental models. These studies help to elucidate the distinct roles of CRF receptor subtypes in the central and peripheral nervous systems.

Laboratory notes

Sauvagine is a potent biological agent; handle with appropriate laboratory precautions and personal protective equipment.
Solubility can be enhanced by reconstituting in a slightly acidic buffer (e.g., 10mM acetic acid) before further dilution into physiological media.
When comparing its effects to CRF or urocortins, be mindful of its distinct receptor subtype selectivity profile (CRF2 > CRF1).

Storage and reconstitution basics: storage guide.

Questions about Sauvagine

What is the origin of sauvagine?

It was first isolated from the skin secretions of the South American waxy monkey tree frog, Phyllomedusa sauvagei.

Which mammalian receptors does sauvagine target?

It is a potent agonist of corticotropin-releasing factor (CRF) receptors, with a higher affinity for the CRF2 receptor subtype compared to the CRF1 subtype.

Why is sauvagine used in research instead of endogenous CRF?

Its different receptor selectivity and greater stability in some contexts make it a useful tool for dissecting the specific functions of the CRF2 receptor pathway.

Is Sauvagine for human use?

No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.

Related research peptides

All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.