Cosmetic · Lipopeptide
Syn-Coll (Palmitoyl Tripeptide-5)
Also known as Palmitoyl Tripeptide-5
A synthetic lipopeptide that mimics thrombospondin I to activate TGF-β, studied in fibroblast cultures for its effects on collagen synthesis.
- Length
- 3 amino acids (plus palmitoyl group)
- Half-life
- Not well characterised
- Mechanism
- It is designed to mimic the thrombospondin I (TSP1) sequence to activate latent transforming growth factor-beta (TGF-β), a key cytokine in collagen synthesis.
- Studied in
- In vitro studies with human dermal fibroblasts are used to evaluate its ability to increase collagen production, ostensibly through the TGF-β pathway.
About Syn-Coll (Palmitoyl Tripeptide-5)
Palmitoyl Tripeptide-5 is a synthetic lipopeptide, also known by a commercial trade name. It comprises a three-amino-acid sequence (Lys-Val-Lys) where the N-terminus is attached to a palmitoyl group. This design is intended to mimic a specific sequence within the protein thrombospondin I (TSP1).
The proposed mechanism of action involves the activation of latent transforming growth factor-beta (TGF-β). TGF-β is a powerful cytokine that exists in an inactive complex in the extracellular matrix. By mimicking the TSP1 binding sequence, Palmitoyl Tripeptide-5 is hypothesized to bind to the latent TGF-β complex and release active TGF-β. This active TGF-β can then signal fibroblasts to increase the synthesis of extracellular matrix proteins, which is the endpoint measured in laboratory studies.
Laboratory notes
- The peptide sequence is Palmitoyl-Lys-Val-Lys (Pal-KVK).
- Its mechanism via TGF-β activation can be confirmed by using TGF-β neutralizing antibodies in cell culture, which should block the peptide's effects.
- This peptide's activity is distinct from Matrixyl (Pal-KTTKS), which is a direct fragment of procollagen, while Pal-KVK mimics a sequence from thrombospondin I.
Storage and reconstitution basics: storage guide.
Questions about Syn-Coll (Palmitoyl Tripeptide-5)
What is TGF-β and why is its activation important in these studies?
Transforming growth factor-beta (TGF-β) is a cytokine that is a master regulator of tissue repair and extracellular matrix production. Activating it in fibroblast cultures is a key pathway for stimulating collagen synthesis.
What is thrombospondin I (TSP1)?
TSP1 is a large, multi-domain glycoprotein found in the extracellular matrix. One of its many biological functions is to bind to and activate latent TGF-β.
How is Palmitoyl Tripeptide-5 different from Palmitoyl Tripeptide-1 (Pal-GHK)?
They are different tripeptides with distinct sequences and proposed mechanisms. Palmitoyl Tripeptide-5 (Pal-KVK) is designed to activate TGF-β. Palmitoyl Tripeptide-1 (Pal-GHK) is a collagen fragment thought to act as a direct 'matrikine' signal for matrix repair.
Is Syn-Coll (Palmitoyl Tripeptide-5) for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.