Tuftsin

Tuftsin is an endogenous tetrapeptide (Thr-Lys-Pro-Arg) that stimulates the activity of phagocytic immune cells like macrophages.

Length: 4 amino acids
Half-life: Short, in the order of minutes in plasma.
Mechanism: It binds to specific receptors on macrophages, neutrophils, and other phagocytic cells, stimulating their phagocytic and bactericidal activities.
Studied in: Investigated in immunology for its effects on phagocyte function, including chemotaxis, motility, and the production of reactive oxygen species.

About Tuftsin

Tuftsin is an endogenous tetrapeptide with the sequence Threonyl-Lysyl-Prolyl-Arginine (TKPR). It is naturally produced when it is enzymatically cleaved from the Fc domain of the heavy chain of immunoglobulin G (IgG). Its existence was inferred from early studies showing that specific spleen-derived factors could activate phagocytic cells.

In a laboratory context, Tuftsin serves as a specific stimulant for phagocytes. Researchers apply it to in vitro cultures of macrophages and neutrophils to study the fundamental mechanisms of phagocytosis, cell migration (chemotaxis), and immunomodulation. Its effects on cellular functions like cytokine release and bactericidal activity are subjects of ongoing immunological investigation.

Laboratory notes

The C-terminal arginine residue is known to be critical for its biological activity.
The peptide is highly soluble in water and aqueous buffers.
Due to its short half-life in biological fluids containing proteases, experiments are typically conducted in controlled in vitro systems.

Storage and reconstitution basics: storage guide.

Questions about Tuftsin

What is the origin of Tuftsin?

It is an endogenous peptide that is cleaved from the constant region (Fc) of the immunoglobulin G (IgG) molecule by specific enzymes in the spleen and on the surface of phagocytes.

What is the main function of Tuftsin in immunological studies?

It is used as a tool to stimulate and study the functions of phagocytic cells, such as macrophages and neutrophils, including their ability to engulf particles and migrate.

Is Tuftsin stable?

Tuftsin itself is susceptible to rapid enzymatic degradation in plasma. Lyophilised Tuftsin is stable, but reconstituted solutions should be used promptly or stored frozen.

Is Tuftsin for human use?

No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.

Related research peptides

All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.