Cosmetic · Lipopeptide
Acetyl Dipeptide-1 Cetyl Ester
Also known as N-Acetyl-L-tyrosyl-L-arginyl-O-hexadecyl ester
A lipopeptide designed for in vitro research into neurosensory pathways, Acetyl Dipeptide-1 Cetyl Ester is studied for its effects on cell signalling.
- Length
- 2 amino acids
- Half-life
- Not well characterised
- Mechanism
- This lipopeptide is designed to modulate sensory nerve responses by interacting with pathways involved in the perception of stimuli in skin cell models.
- Studied in
- It is studied in neuronal and keratinocyte co-culture systems to examine its effects on neurosensory signalling and the release of pro-inflammatory mediators.
About Acetyl Dipeptide-1 Cetyl Ester
Acetyl Dipeptide-1 Cetyl Ester is a synthetic lipopeptide, which combines the dipeptide Tyr-Arg with an acetyl group at the N-terminus and a cetyl ester at the C-terminus. The lipidic cetyl ester modification is intended to enhance its partitioning into lipid-rich environments, such as cell membranes, a key factor in its design for in vitro assays.
This compound's research focus is within the field of neurocosmetic science and cell signalling. Laboratory studies investigate its ability to modulate cellular responses to external stimuli in models of skin sensitivity. It is hypothesised to influence the release of calcitonin gene-related peptide (CGRP) from sensory neurons, thereby affecting communication between nerve cells and keratinocytes.
Laboratory notes
- The molecule combines a dipeptide (Tyrosine-Arginine) with acetyl and cetyl ester groups.
- Due to the cetyl ester group, it is highly lipophilic; appropriate solvents are required for solubilisation.
- Often used in cell culture assays measuring markers like Calcitonin Gene-Related Peptide (CGRP) or substance P release.
Storage and reconstitution basics: storage guide.
Questions about Acetyl Dipeptide-1 Cetyl Ester
What is the composition of this molecule?
It is a dipeptide (Tyrosine-Arginine) that has been acetylated at the N-terminus and esterified with cetyl alcohol at the C-terminus, making it a lipopeptide.
Why does it have a cetyl ester modification?
The cetyl ester is a 16-carbon lipid chain. This modification increases the molecule's lipophilicity, which is theorised to facilitate its interaction with cell membranes in experimental systems.
What type of in vitro models is this peptide used in?
It is primarily used in in vitro models of skin neurosensation, often involving co-cultures of keratinocytes and dorsal root ganglia (DRG) neurons to study cell-to-cell communication.
Is Acetyl Dipeptide-1 Cetyl Ester for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.