Cosmetic · Synthetic Tetrapeptide
Tetrapeptide-30
Tetrapeptide-30 is a synthetic peptide used in cell culture research to study mechanisms of skin pigmentation and inflammatory signalling pathways.
- Length
- 4 amino acids
- Half-life
- Not well characterised
- Mechanism
- This peptide is investigated for its ability to interfere with the pro-inflammatory cytokine interleukin-6 (IL-6) pathway in keratinocytes, which may in turn influence melanocyte activity.
- Studied in
- In vitro studies on melanocyte-keratinocyte co-cultures examine its effects on melanin synthesis, tyrosinase activity, and the expression of pigmentation-related markers.
About Tetrapeptide-30
Tetrapeptide-30 is a synthetic peptide with the four amino acid sequence Pro-Lys-Glu-Lys (PKEK). It was developed through screening processes to identify peptides that could modulate pathways related to skin pigmentation. Its structure is designed for stability and activity in aqueous cell culture media.
This peptide is a subject of research in skin biology, specifically focusing on melanogenesis. In vitro models, such as co-cultures of human keratinocytes and melanocytes, are employed to investigate its potential to decrease tyrosinase activity and melanin production. The underlying mechanism studied involves the inhibition of keratinocyte-derived pro-melanogenic signals.
Laboratory notes
- The amino acid sequence is Pro-Lys-Glu-Lys (PKEK).
- Research often focuses on its interaction with the plasminogen/plasmin system and its downstream effects on alpha-MSH activation.
- Assays typically measure melanin content, tyrosinase enzyme activity, and POMC gene expression in cultured cells.
Storage and reconstitution basics: storage guide.
Questions about Tetrapeptide-30
What is the sequence of Tetrapeptide-30?
The amino acid sequence is Proline-Lysine-Glutamic acid-Lysine (PKEK).
What is the primary area of research for Tetrapeptide-30?
It is used in cell biology research to investigate the molecular pathways of skin pigmentation, particularly the communication between keratinocytes and melanocytes.
What cellular processes are studied with this peptide?
Researchers use Tetrapeptide-30 to study its effects on tyrosinase expression, melanin synthesis, and the signalling molecules that regulate melanocyte function in controlled in vitro environments.
Is Tetrapeptide-30 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.