Cosmetic · Lipopeptide
Palmitoyl Tripeptide-38
Palmitoyl Tripeptide-38 is a lipopeptide researched for its role in stimulating extracellular matrix protein synthesis in fibroblast cell culture models.
- Length
- 3 amino acids
- Half-life
- Not well characterised
- Mechanism
- This peptide is derived from a tripeptide sequence found in collagen VI and laminin-5, and it is studied for its ability to stimulate the synthesis of various extracellular matrix proteins.
- Studied in
- In vitro fibroblast cultures are used to investigate its effect on the gene expression and synthesis of matrix components including multiple collagen types and hyaluronic acid.
About Palmitoyl Tripeptide-38
Palmitoyl Tripeptide-38 is a synthetic lipopeptide created by conjugating palmitic acid to a tripeptide with the sequence Lys-Met(O2)-Lys. This tripeptide is derived from a conserved motif found in key extracellular matrix (ECM) proteins, namely collagen VI and laminin-5. The addition of the palmitoyl group enhances its lipophilicity and stability in experimental preparations.
The primary application of this peptide in laboratory research is the study of ECM synthesis and tissue architecture. In fibroblast cell cultures, it is used as a tool to investigate the upregulation of genes responsible for producing essential matrix components. These include collagen I, III, IV, fibronectin, hyaluronic acid, and laminin-5, providing a model for studying mechanisms of matrix remodeling.
Laboratory notes
- The peptide sequence corresponds to a fragment of collagen VI and laminin-5.
- The methionine residue is in its oxidized sulfone form, Met(O2).
- Used as a research-grade compound to study mechanisms attributed to the commercial ingredient Matrixyl Synthe'6.
Storage and reconstitution basics: storage guide.
Questions about Palmitoyl Tripeptide-38
What is the base peptide sequence of Palmitoyl Tripeptide-38?
The base peptide is a tripeptide with the sequence Lys-Met(O2)-Lys, where the methionine is an oxidized sulfone.
Why is a palmitoyl group attached?
The palmitoyl group is a lipid moiety that increases the peptide's lipophilicity. This modification is designed to improve its stability and interaction with cellular membranes in experimental settings.
What matrix proteins are studied in relation to this peptide?
Research with Palmitoyl Tripeptide-38 in fibroblast cultures often measures changes in the expression and synthesis of collagen I, III, IV, fibronectin, hyaluronic acid, and laminin-5.
Is Palmitoyl Tripeptide-38 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.