Cognitive · Hexapeptide
Angiotensin IV
Also known as Angiotensin-(3-8)
Angiotensin IV is a hexapeptide fragment of angiotensin II studied for its unique binding to the AT4 receptor and its effects on cognition in lab models.
- Length
- 6 amino acids
- Half-life
- Less than 1 minute in plasma
- Mechanism
- This peptide binds to the AT4 receptor, also known as insulin-regulated aminopeptidase (IRAP), rather than the classical AT1 or AT2 receptors.
- Studied in
- Its potential role in memory formation, cognitive processes, and cerebral blood flow regulation is investigated in various cell and animal models.
About Angiotensin IV
Angiotensin IV is the (3-8) fragment of the parent hormone angiotensin II, composed of the amino acid sequence Val-Tyr-Ile-His-Pro-Phe. Unlike its precursor, it exhibits minimal activity at the AT1 and AT2 receptors. Its primary binding site is the AT4 receptor, an enzyme also identified as insulin-regulated aminopeptidase (IRAP).
In laboratory research, angiotensin IV is explored for its effects on cognitive function and neural plasticity. Studies often focus on its interaction with IRAP and downstream signalling pathways in models of memory and learning, as well as its potential influence on cerebral microcirculation.
Laboratory notes
- Prone to rapid degradation by peptidases in serum-containing media, which is a critical factor in experimental design.
- Stock solutions are typically prepared in sterile water or aqueous buffers and should be aliquoted and stored frozen.
- Due to its short half-life, in vivo studies may require continuous infusion or co-administration with peptidase inhibitors for sustained effect.
Storage and reconstitution basics: storage guide.
Questions about Angiotensin IV
What is Angiotensin IV's primary receptor?
Angiotensin IV primarily binds to the AT4 receptor, which is distinct from the AT1 and AT2 receptors targeted by other angiotensin peptides.
How is Angiotensin IV related to Angiotensin II?
It is a biologically active hexapeptide fragment derived from Angiotensin II, corresponding to amino acids 3 through 8.
Is Angiotensin IV stable?
In biological fluids and standard cell culture media, it is rapidly degraded by peptidases. This instability is a critical consideration for designing experiments.
Is Angiotensin IV for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
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