Cosmetic · Synthetic Hexapeptide
Hexapeptide-10
Also known as Serilesine
Hexapeptide-10 is a synthetic peptide containing a laminin-derived sequence used in cell culture to study cellular adhesion and dermal-epidermal junction integrity.
- Length
- 6 amino acids
- Half-life
- Not well characterised
- Mechanism
- This peptide contains a sequence derived from laminin which facilitates cell adhesion and interaction with integrin receptors.
- Studied in
- It is investigated in cell culture models for its effects on cell adhesion, proliferation, and migration, particularly in keratinocytes and fibroblasts.
About Hexapeptide-10
Hexapeptide-10 is a synthetic peptide with the amino acid sequence Ser-Ile-Lys-Val-Ala-Val (SIKVAV). This sequence is derived from the α-chain of laminin, a key protein component of the basement membrane. Its structure is designed to mimic the cell-binding domain of laminin.
Research applications for Hexapeptide-10 focus on its role in cell-matrix interactions. In vitro studies using keratinocyte and fibroblast cell lines explore its capacity to promote cell adhesion, migration, and proliferation, providing insights into the molecular mechanisms that maintain the integrity of the dermal-epidermal junction.
Laboratory notes
- The sequence Ser-Ile-Lys-Val-Ala-Val (SIKVAV) is derived from the alpha-1 chain of laminin.
- Often studied in co-culture systems of keratinocytes and fibroblasts to model the dermal-epidermal junction.
- Solubility and stability in aqueous solutions should be confirmed for specific experimental buffer systems.
Storage and reconstitution basics: storage guide.
Questions about Hexapeptide-10
What is the sequence of Hexapeptide-10?
The amino acid sequence for Hexapeptide-10 is Ser-Ile-Lys-Val-Ala-Val (SIKVAV).
Which natural protein does Hexapeptide-10 mimic?
Hexapeptide-10 mimics a functional sequence from the alpha-1 chain of laminin, an essential protein in the basement membrane that connects the dermis and epidermis.
What is the significance of the SIKVAV sequence?
The SIKVAV sequence is a cell-binding motif. It is investigated for its ability to interact with cellular integrin receptors, influencing cell adhesion and signalling processes in laboratory models.
Is Hexapeptide-10 for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or animal consumption.
Related research peptides
All products are sold for laboratory research use only. Not for human consumption, not a medicine, not for diagnosing, treating or preventing any condition.